Sawai T, Usui N, Sando K, Fukui Y, Kamata S, Okada A, Taniguchi N, Itano N, Kimata K
Department of Pediatric Surgery and Biochemistry, Japan.
J Pediatr Surg. 1997 Jan;32(1):41-3. doi: 10.1016/s0022-3468(97)90089-0.
Fetal wound healing proceeds without fibrosis or scar formation in contrast to adult wound healing. The mechanisms responsible for this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid (HA). Polyvinylalcohol sponge (PVA) wound implants were placed pervertebrally at 24 days' gestation in fetal (N = 118) rabbits and in adult (N = 44) rabbits, and then harvested at 1, 2, 3, 4, 5, and 7 days postwounding. To analyze the fetal and adult wound matrix, the HA concentration of wound fluid within the PVA sponge was quantitated using a newly developed assay. A significantly increased (P < .05) HA deposition on days 1 through 7 in the fetal wounds was found compared with the adult wound. These observations may suggest an important physiologic role in fetal wound healing by providing a more fluid and malleable matrix. These results, coupled with earlier findings of the lack of an acute inflammatory response in the fetus, further support the hypothesis that fetal response to injury is significantly different from adult response in this prescience of an implanted PVA sponge.
与成年伤口愈合不同，胎儿伤口愈合过程中不会出现纤维化或瘢痕形成。这一显著过程的机制部分是通过富含透明质酸（HA）的胎儿伤口细胞外基质介导的。在妊娠24天的胎儿（N = 118）和成年（N = 44）兔的椎旁植入聚乙烯醇海绵（PVA）伤口植入物，然后在受伤后1、2、3、4、5和7天进行收获。为了分析胎儿和成年伤口基质中，使用一种新开发的检测方法对PVA海绵内伤口液中的HA浓度进行了定量。与成年伤口相比，发现胎儿伤口在第1至7天的HA沉积显著增加（P < 0.05）。这些观察结果可能表明，通过提供更具流动性和可塑性的基质，HA在胎儿伤口愈合中具有重要的生理作用。这些结果，再加上早期关于胎儿缺乏急性炎症反应的发现，进一步支持了这样的假设，即在植入PVA海绵的情况下，胎儿对损伤的反应与成年反应显著不同。
