Department of Ophthalmology, University of Bonn, Bonn, Germany; Department of Biomedical Data Science, Stanford University, Stanford, USA.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Prog Retin Eye Res. 2021 May;82:100907. doi: 10.1016/j.preteyeres.2020.100907. Epub 2020 Oct 3.
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP can provide insightful information about disease severity and progression not reflected by best-corrected visual acuity in a large range of disorders. This is especially important for monitoring of retinal diseases that initially spare the central retina in earlier disease stages. Improved intra- and inter-session retest-variability through fundus-tracking and precise point-wise follow-up examinations even in patients with unstable fixation represent key advantages of these technique. The design of disease-specific test patterns and protocols reduces the burden of extensive and time-consuming FCP testing, permitting a more meaningful and focused application. Recent developments also allow for photoreceptor-specific testing through implementation of dark-adapted chromatic and photopic testing. A detailed understanding of the variety of available devices and test settings is a key prerequisite for the design and optimization of FCP protocols in future natural history studies and clinical trials. Accordingly, this review describes the theoretical and technical background of FCP, its prior application in clinical and research settings, data that qualify the application of FCP as an outcome measure in clinical trials as well as ongoing and future developments.
眼底控制视野计（FCP，也称为“微视野计”）允许对视觉灵敏度进行空间分辨映射，并测量注视稳定性，无论是在临床实践中还是在研究中。FCP 实现的视觉功能的精确空间特征可以提供有关疾病严重程度和进展的有见地的信息，而这些信息在很大程度上不能通过最佳矫正视力反映出来。对于监测在早期疾病阶段最初保留中心视网膜的视网膜疾病，这一点尤为重要。通过眼底跟踪和精确的点式随访检查，可以提高内和间测试变异性，即使在固定不稳定的患者中也能如此，这是这些技术的关键优势。特定疾病的测试模式和协议的设计可以减少广泛而耗时的 FCP 测试的负担，从而使测试更有意义和更有针对性。最近的发展还允许通过实施暗适应色觉和明适应测试来进行光感受器特异性测试。详细了解各种可用设备和测试设置是未来自然史研究和临床试验中设计和优化 FCP 协议的关键前提。因此，本综述描述了 FCP 的理论和技术背景、其在临床和研究环境中的先前应用、将 FCP 作为临床试验中结果测量的应用的合格数据以及正在进行和未来的发展。
