Ma D D, Da W M, Purvis-Smith S, Biggs J C
Leuk Res. 1987;11(7):661-3. doi: 10.1016/0145-2126(87)90040-3.
Karyotyping was performed on bone marrow stromal fibroblasts and marrow haemopoietic cells on six patients who received bone marrow transplants from siblings of the opposite sex. Three patients with severe aplastic anaemia received unmanipulated donor bone marrow cells. Three other patients with leukaemia and conditioned with high dose chemotherapy (+ total body irradiation in two patients) received T-cell depleted marrow mononuclear cells. Marrow chromosomal analysis was performed on samples obtained between 6 weeks and 1 yr post-transplant. All marrow fibroblasts studied were of recipient origin, whereas all haemopoietic cells were of donor origin. These results demonstrate that in allogeneic sibling marrow transplantation, recipient bone marrow stromal cells regenerate and repopulate the bone marrow and this is not influenced by the conditioning regimen used, the type and dose of marrow cells given and the pre-existing disease.
对6名接受异性同胞骨髓移植的患者的骨髓基质成纤维细胞和骨髓造血细胞进行了核型分析。3名严重再生障碍性贫血患者接受了未处理的供体骨髓细胞。另外3名白血病患者在接受高剂量化疗（2名患者还接受了全身照射）预处理后，接受了去除T细胞的骨髓单个核细胞。在移植后6周和1年之间采集的样本上进行了骨髓染色体分析。所有研究的骨髓成纤维细胞均来自受体，而所有造血细胞均来自供体。这些结果表明，在同种异体同胞骨髓移植中，受体骨髓基质细胞可再生并重新填充骨髓，且这不受所用预处理方案、所给骨髓细胞的类型和剂量以及原有疾病的影响。
