Martins Cleodice Alves, França Ana Karina Teixeira da Cunha, Dias Raimunda Sheyla Carneiro, Costa Rayanna Cadilhe de Oliveira, Lemos Antônio Pedro Leite, Santos Alcione Miranda Dos, Hortegal Elane Viana, Brito Dyego José de Araújo
Universidade Federal do Maranhão, Hospital Universitário Presidente Dutra, Programa de Residência Multiprofissional em Saúde, São Luis, MA, Brasil.
Universidade Federal do Maranhão, Departamento de Ciências Fisiológicas, Curso de Nutrição, São Luis, MA, Brasil.
Rev Assoc Med Bras (1992). 2020 Sep;66(9):1235-1240. doi: 10.1590/1806-9282.66.9.1235.
Sarcopenia is characterized by the involuntary loss of lean body mass associated with a progressive reduction of muscle strength.
To determine the prevalence of sarcopenia in kidney transplant recipients and its association with the determining factors that control muscle homeostasis.
We evaluated renal transplant recipients undergoing follow-up at the University Hospital of the Federal University of Maranhão from June 2017 to July 2018 and who met the inclusion criteria. Sarcopenia was defined according to the European criteria. The skeletal muscle mass index was measured by dual-energy radiological absorptiometry; the values <7,26 kg/m2 for men and <5,5 kg/m2 for women were adopted for muscle depletion. For handgrip strength, values of <30 kg for men and <20 kg for women were considered as reduced muscle strength. In both sexes, the cutoff point for walking speed was <0,8 m/s.
We evaluated 83 renal transplant recipients with a mean age of 48.8 ± 12,1 years and predominantly males (57,8%). The prevalence of sarcopenia was 19,3%. Among individuals without sarcopenia, 17,9% had a decrease in handgrip strength and 40,3% has altered gait speed.
Individuals submitted to renal transplant may develop sarcopenia while still young and already present altered muscle function and strength even before the depletion of lean body mass.
Early diagnosis may allow the prevention of sarcopenia and provide a better quality of life for patients.
肌肉减少症的特征是瘦体重的非自愿性丧失，并伴有肌肉力量的逐渐下降。
确定肾移植受者中肌肉减少症的患病率及其与控制肌肉稳态的决定因素之间的关联。
我们评估了2017年6月至2018年7月在马拉尼昂联邦大学大学医院接受随访且符合纳入标准的肾移植受者。根据欧洲标准定义肌肉减少症。通过双能放射吸收法测量骨骼肌质量指数；男性<7.26kg/m²、女性<5.5kg/m²的值被用作肌肉减少的标准。对于握力，男性<30kg、女性<20kg的值被视为肌肉力量下降。在男女两性中，步行速度的临界值均为<0.8m/s。
我们评估了83名肾移植受者，平均年龄为48.8±12.1岁，以男性为主（57.8%）。肌肉减少症的患病率为19.3%。在没有肌肉减少症 的个体中，17.9%的人握力下降，40.3%的人步态速度改变。
接受肾移植的个体可能在年轻时就出现肌肉减少症，甚至在瘦体重减少之前就已经出现肌肉功能和力量的改变。
早期诊断可能有助于预防肌肉减少症，并为患者提供更好的生活质量。
