Janczar Szymon, Bulas Monika, Walenciak Justyna, Baranska Dobromila, Ussowicz Marek, Młynarski Wojciech, Zalewska-Szewczyk Beata
Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Sporna 36/50 St., 91-738 Lodz, Poland.
Department of Diagnostic Imaging, Polish Mother's Memorial Hospital Research Institute, 91-738 Lodz, Poland.
Children (Basel). 2020 Oct 5;7(10):169. doi: 10.3390/children7100169.
Toxocariasis is one of the most common zoonoses, with high seroprevalence in apparently healthy individuals. Neuroblastoma is an aggressive childhood cancer. The cure rates are improving due to dose-dense chemotherapy, progress in surgical practice, myeloablative therapy with autologous stem cell transplantation, and recently, anti-GD2 immunotherapy. This is associated with a burden of complications, some of which are relatively specific for neuroblastoma treatment. Based on previous reports of infection in high-risk neuroblastoma patients and cases of pulmonary exacerbation from our center in this disease, we propose that toxocariasis is a specific complication of intensive pediatric cancer treatment and advocate for active surveillance.
弓蛔虫病是最常见的人畜共患病之一，在看似健康的个体中血清阳性率很高。神经母细胞瘤是一种侵袭性儿童癌症。由于剂量密集化疗、外科手术进展、自体干细胞移植的清髓治疗以及最近的抗GD2免疫治疗，治愈率正在提高。这伴随着并发症负担，其中一些并发症相对特定于神经母细胞瘤治疗。基于先前关于高危神经母细胞瘤患者感染的报道以及我们中心在这种疾病中出现肺部病情加重的病例，我们提出弓蛔虫病是儿童强化癌症治疗的一种特定并发症，并主张进行积极监测。
