信使核糖核酸——从新冠治疗到癌症免疫疗法

Independent Researcher, 13505 Berlin, Germany.

Biomedicines. 2023 Jan 22;11(2):308. doi: 10.3390/biomedicines11020308.

This review provides an overview covering mRNA from its use in the COVID-19 pandemic to cancer immunotherapy, starting from the selection of appropriate antigens, tumor-associated and tumor-specific antigens, neoantigens, the basics of optimizing the mRNA molecule in terms of stability, efficacy, and tolerability, choosing the best formulation and the optimal route of administration, to summarizing current clinical trials of mRNA vaccines in tumor therapy.

本综述概述了信使核糖核酸（mRNA）从其在新冠疫情中的应用到癌症免疫治疗的情况，内容涵盖从选择合适的抗原（肿瘤相关抗原、肿瘤特异性抗原、新抗原），到在稳定性、有效性和耐受性方面优化mRNA分子的基础知识，再到选择最佳配方和最优给药途径，直至总结mRNA疫苗在肿瘤治疗中的当前临床试验情况。