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一种用于治疗肝移植术后胆道吻合口狭窄的独特的全覆膜金属支架。

A unique type of fully covered metal stent for the management of post liver transplant biliary anastomotic strictures.

作者信息

Warner Ben, Harrison Phillip, Farman Muhammad, Devlin John, Reffitt David, El-Sherif Yasser, Khorsandi Shirin E, Prachalias Andreas, Cerisuelo Miriam Cortes, Menon Krish, Jassem Wayel, Srinivasan Parthi, Vilca-Melendez Hector, Heneghan Michael, Heaton Nigel, Joshi Deepak

机构信息

Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.

出版信息

BMC Gastroenterol. 2020 Oct 7;20(1):329. doi: 10.1186/s12876-020-01479-6.

Abstract

BACKGROUND

We report our experience of treating anastomotic strictures using a novel type of fully covered metal stent (FCSEMS). This stent, known as the Kaffes Stent, is short-length with an antimigration waist and is easily removable due to long retrieval wires deployed within the duodenum.

METHODS

Sixty-two patients underwent ERCP and Kaffes stent insertion for post-transplant anastomotic strictures following confirmation of a stricture on MRCP. These patients were retrospectively analysed for immediate and long-term stricture resolution, improvement in symptoms and liver function tests (LFTs), stricture recurrence and complication rates.

RESULTS

Of the 56 patients who had their stent removed at the time of analysis, 54 (96%) had immediate stricture resolution and 42 continued to have long-term resolution (mean follow-up period was 548 days). Of the 16 patients with symptoms of biliary obstruction, 13 had resolution of their symptoms. Overall, there was a significant improvement in LFTs after stent removal compared to before stent insertion. Complication rates were 15% with only one patient requiring biliary reconstruction.

CONCLUSIONS

The Kaffes stent is effective and safe at resolving post liver transplant biliary anastomotic strictures.

摘要

背景

我们报告了使用新型全覆膜金属支架(FCSEMS)治疗吻合口狭窄的经验。这种支架被称为卡费斯支架,长度较短,有防移位腰部,由于十二指肠内有长的回收线,易于取出。

方法

62例患者在磁共振胰胆管造影(MRCP)证实存在狭窄后,接受了内镜逆行胰胆管造影(ERCP)及卡费斯支架置入术,以治疗移植后吻合口狭窄。对这些患者进行回顾性分析,以评估即刻和长期狭窄缓解情况、症状改善情况以及肝功能检查(LFTs)结果、狭窄复发情况和并发症发生率。

结果

在分析时已取出支架的56例患者中,54例(96%)即刻狭窄缓解,42例持续保持长期缓解(平均随访期为548天)。16例有胆道梗阻症状的患者中,13例症状缓解。总体而言,与支架置入前相比,取出支架后肝功能检查有显著改善。并发症发生率为15%,只有1例患者需要进行胆道重建。

结论

卡费斯支架在解决肝移植后胆道吻合口狭窄方面有效且安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5089/7539398/ee3a2b24c0d0/12876_2020_1479_Fig1_HTML.jpg

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