Diallo K, Revuz S, Clavel-Refregiers G, Sené T, Titah C, Gerfaud-Valentin M, Seve P, Jaussaud R
Department of Internal Medicine, Nancy University Hospital, Nancy, France.
Department of Internal Medicine, Metz Private Hospital, Metz, France.
BMC Ophthalmol. 2020 Oct 7;20(1):395. doi: 10.1186/s12886-020-01656-x.
East and South East Asian subjects as well as Amerindians and Hispanic subjects are predominantly affected by Vogt-Koyanagi-Harada disease. In Europe, only few studies have described the clinical features and treatment of this disease, especially in France.
This retrospective case series was based on data collected from patients with a VKH disease diagnosed from January 2000 to March 2017, provided by three French Tertiary Centers.
Forty-one patients (16 men and 25 women) were diagnosed: average age at diagnosis was 38.7 years. Patients were mainly from Maghreb (58%), but ethnic origins were multiple. Pleiocytosis was observed in 19 cases (63%) and 17 out of 41 patients showed audio vestibular signs (41%), and 11 showed skin signs (27%). Thirty-four were treated with corticosteroids (83%), 11 with an immunosuppressant treatment (27%) and 5 with biological therapy drugs (13%). Relapse was observed in 41% patients, even though final average visual acuity had improved. We did not find any significant clinical difference in the population from Maghreb compared to other populations, but for age and sex trends, since there was a majority of younger women.
We report here the second largest French cohort reported to date to our knowledge. The multiethnicity in our study suggests that VKH disease should be evoked whatever patients' ethnicity.
东亚和东南亚人群以及美洲印第安人和西班牙裔人群主要受伏格特-小柳-原田病影响。在欧洲，只有少数研究描述了这种疾病的临床特征和治疗方法，尤其是在法国。
本回顾性病例系列基于从2000年1月至2017年3月诊断为伏格特-小柳-原田病的患者收集的数据，这些数据由法国三个三级医疗中心提供。
共诊断出41例患者（16名男性和25名女性）：诊断时的平均年龄为38.7岁。患者主要来自马格里布地区（58%），但种族来源多样。19例（63%）出现脑脊液细胞增多，41例患者中有17例出现听觉前庭症状（41%），11例出现皮肤症状（27%）。34例接受了皮质类固醇治疗（83%），11例接受了免疫抑制治疗（27%），5例接受了生物治疗药物（13%）。41%的患者出现复发，尽管最终平均视力有所改善。与其他人群相比，我们未发现马格里布人群有任何显著的临床差异，但在年龄和性别趋势方面存在差异，因为年轻女性占多数。
据我们所知，我们在此报告了法国迄今为止第二大的队列研究。我们研究中的多民族性表明，无论患者种族如何，都应考虑伏格特-小柳-原田病。
