School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
College of Nursing, Michigan State University, East Lansing, MI, USA.
Health Qual Life Outcomes. 2020 Oct 7;18(1):332. doi: 10.1186/s12955-020-01580-0.
When curative treatments are no longer available for cancer patients, the aim of treatment is palliative. The emphasis of palliative care is on optimizing quality of life and provided support for patients nearing end of life. However, chemotherapy is often offered as a palliative therapy for patients with advanced cancer nearing death. The purpose of this review was to evaluate the state of the science relative to use of palliative chemotherapy and maintenance of quality of life in patients with advanced cancer who were at end of life.
Published research from January 2010 to December 2019 was reviewed using PRISMA guidelines using PubMed, Proquest, ISI web of science, Science Direct, and Scopus databases. MeSH keywords including quality of life, health related quality of life, cancer chemotherapy, drug therapy, end of life care, palliative care, palliative therapy, and palliative treatment.
13 studies were evaluated based on inclusion criteria. Most of these studies identified that reduced quality of life was associated with receipt of palliative chemotherapy in patients with advanced cancer at the end of life.
Studies have primarily been conducted in European and American countries. Cultural background of patients may impact quality of life at end of life. More research is needed in developing countries including Mideastern and Asian countries.
当癌症患者不再有治愈性治疗方法时，治疗的目的是姑息治疗。姑息治疗的重点是优化生活质量，并为接近生命终点的患者提供支持。然而，对于接近死亡的晚期癌症患者，化疗常常被作为姑息疗法。本综述的目的是评估姑息化疗在接近生命终点的晚期癌症患者中维持生活质量的科学现状。
使用 PRISMA 指南，检索了 2010 年 1 月至 2019 年 12 月发表的研究，检索了 PubMed、Proquest、ISI web of science、Science Direct 和 Scopus 数据库。MeSH 关键词包括生活质量、健康相关生活质量、癌症化疗、药物治疗、生命终末期护理、姑息治疗、姑息疗法和姑息治疗。
根据纳入标准，评估了 13 项研究。这些研究大多表明，在接近生命终点的晚期癌症患者中，接受姑息化疗与生活质量下降有关。
这些研究主要在欧洲和美国进行。患者的文化背景可能会影响生命终末期的生活质量。需要在包括中东和亚洲国家在内的发展中国家开展更多的研究。
