与活动性丙型肝炎病毒（HCV）感染患者相比，丙型肝炎病毒感染康复者循环中IL-10水平升高。

Increased levels of circulating IL-10 in persons recovered from hepatitis C virus (HCV) infection compared with persons with active HCV infection.

作者信息

Owusu Dorcas Ohui, Phillips Richard, Owusu Michael, Sarfo Fred Stephen, Frempong Margaret

机构信息

Department of Medical Laboratory Technology, Garden City University College (GCUC), P.O. Box 12775, Kumasi, Ghana.

Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology (KNUST), PMB, KNUST, Kumasi, Ghana.

出版信息

BMC Res Notes. 2020 Oct 7;13(1):472. doi: 10.1186/s13104-020-05313-w.

DOI:10.1186/s13104-020-05313-w

PMID:33028385

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7542684/

Abstract

OBJECTIVE

Approximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achieving viral clearance is still not well understood. Thus, the current study was set to determine the relationship between the T cell cytokine profiles, biochemical parameters and persistent HCV infection or spontaneous recovery.

RESULTS

Twenty-five percent (41/163) of the anti-HCV positive participants had recovered from HCV and had significantly higher concentration of IL-10 compared to those with active HCV infection (P < 0.012). Other circulating cytokines measured; IL-2, IFN gamma, TNF alpha, IL-5 and IL-17 were similar in both groups. Participants with active HCV infection had significantly higher aspartate transaminase (AST) (35 units) and alanine transaminase (46 units) compared to those in the recovered state (P < 0.001). Thus, serum levels of IL10 could be explored in larger prospective cohort study as a predictive marker of recovering from an active HCV infection.

摘要

目的

约70%的丙型肝炎病毒（HCV）感染会发展为慢性病。活动性或加重的慢性丙型肝炎感染随后会进展为肝病。T细胞分泌物在实现病毒清除中的作用仍未完全了解。因此，本研究旨在确定T细胞细胞因子谱、生化参数与持续性HCV感染或自发恢复之间的关系。

结果

25%（41/163）的抗HCV阳性参与者已从HCV中恢复，与活动性HCV感染参与者相比，其IL-10浓度显著更高（P < 0.012）。所检测的其他循环细胞因子；两组中的IL-2、γ干扰素、肿瘤坏死因子α、IL-5和IL-17相似。与恢复状态的参与者相比，活动性HCV感染的参与者的天冬氨酸转氨酶（AST）（35单位）和丙氨酸转氨酶（46单位）显著更高（P < 0.001）。因此，在更大规模的前瞻性队列研究中，可以探索血清IL10水平作为从活动性HCV感染中恢复的预测标志物。