流产、死胎和治疗性人工流产后女性心血管疾病风险的系统评价和荟萃分析方案。
The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion: a protocol for a systematic review and meta-analysis.
机构信息
School of Clinical Medicine, University of Cambridge, Cambridge, England.
Essex County Council, County Hall, Chelmsford, Essex, CM1 1QH, England.
出版信息
Syst Rev. 2020 Oct 7;9(1):234. doi: 10.1186/s13643-020-01444-0.
BACKGROUND
Cardiovascular disease (CVD) is the leading cause of death in women, responsible for approximately a third of all female deaths. Pregnancy complications are known to be associated with a greater risk of incident CVD in mothers. However, the relationships between pregnancy loss due to miscarriage, stillbirth, or therapeutic abortion, and future maternal cardiovascular health are under-researched. This study seeks to provide an up-to-date systematic review and meta-analysis of the relationship between these three forms of pregnancy loss and the subsequent development of CVD.
METHODS
This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis checklist (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) Checklist. A systematic search will be undertaken using publications identified in MEDLINE (PubMed), Scopus, Web of Knowledge, the CINAHL Nursing Database, and the Cochrane Library. The eligibility of each publication will be determined by predefined selection criteria. The quality of the included studies will be rated using the Newcastle-Ottawa Scale. Pooled measures of association will be computed using random-effects model meta-analyses. Between-study heterogeneity will be assessed using the I statistic and the Cochrane χ statistic. Small study effects will be evaluated for meta-analyses with sufficient studies through the use of funnel plots and Egger's test.
DISCUSSION
The results of this systematic review will discuss the long-term risks of multiple types of cardiovascular disease in women who have experienced miscarriage, stillbirth, and/or therapeutic abortion. It will contribute to the growing field of cardio-obstetrics as the first to consider the full breadth of literature regarding the association between all forms of pregnancy loss and future maternal cardiovascular disease.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO registration number [CRD42020167587].
背景
心血管疾病（CVD）是女性死亡的主要原因，约占女性死亡人数的三分之一。已知妊娠并发症与母亲发生 CVD 的风险增加有关。然而，由于流产、死胎或治疗性流产而导致的妊娠丢失与未来母亲心血管健康之间的关系尚未得到充分研究。本研究旨在对这三种形式的妊娠丢失与随后发生 CVD 的关系进行最新的系统综述和荟萃分析。
方法
本系统综述将遵循系统评价和荟萃分析报告的首选报告项目（PRISMA）和观察性研究荟萃分析的流行病学（MOOSE）清单。将使用 MEDLINE（PubMed）、Scopus、Web of Knowledge、CINAHL 护理数据库和 Cochrane 图书馆中确定的出版物进行系统搜索。将根据预定义的选择标准确定每个出版物的资格。将使用纽卡斯尔-渥太华量表对纳入研究的质量进行评分。使用随机效应模型荟萃分析计算汇总关联的度量。使用 I 统计量和 Cochrane χ 统计量评估研究间的异质性。对于具有足够研究的荟萃分析，将通过使用漏斗图和 Egger 检验评估小研究效应。
讨论
本系统综述的结果将讨论经历过流产、死胎和/或治疗性流产的女性发生多种类型 CVD 的长期风险。它将为心脏妇产科领域的发展做出贡献，因为它是第一个考虑与所有形式的妊娠丢失与未来母亲心血管疾病相关的文献的全面性。
系统综述注册
PROSPERO 注册号[CRD42020167587]。
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