Reynaud A, Drugeon H B, Courtieu A L
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):545-9.
Activity of cefotaxime associated with one of nine other antibiotics (amikacin, dibekacin, gentamicin, netilmicin, sisomicin, tobramycin, erythromycin, clindamycin, and chloramphenicol) was studied by a checkerboard method with determination of FIC and FBC-indices. Four S. aureus strains were used: one homogeneous methicillin-resistant strain (S1), one heterogeneous methicillin-resistant strain (S2), and two susceptible strains (S3 and S4). Strong synergism between cefotaxime and aminoglycosides was found only for S2, with no significant differences between aminoglycosides (index # 0.3). Cefotaxime and chloramphenicol showed synergistic or additive bacteriostatic activities and consistently antagonist bactericidal activities. Bactericidal activities of cefotaxime and erythromycin were likewise antagonistic, whereas cefotaxime and clindamycin occasionally exhibited in vitro synergism.
采用棋盘法并测定FIC和FBC指数，研究了头孢噻肟与其他九种抗生素（阿米卡星、双去氧卡那霉素、庆大霉素、奈替米星、西索米星、妥布霉素、红霉素、克林霉素和氯霉素）之一的联合活性。使用了四株金黄色葡萄球菌菌株：一株同源耐甲氧西林菌株（S1）、一株异源耐甲氧西林菌株（S2）以及两株敏感菌株（S3和S4）。仅在S2菌株中发现头孢噻肟与氨基糖苷类之间有强协同作用，氨基糖苷类之间无显著差异（指数#0.3）。头孢噻肟和氯霉素表现出协同或相加的抑菌活性，且始终表现出拮抗杀菌活性。头孢噻肟和红霉素的杀菌活性同样具有拮抗作用，而头孢噻肟和克林霉素偶尔表现出体外协同作用。
