Lambert-Zechovsky N, Lévêque B, Bingen E, Pillion G, Chapelle J, Mathieu H
Pathol Biol (Paris). 1987 May;35(5):669-72.
Twelve children (mean age: 4) are treated in practice office with nitroxoline (200 mg/kg/24 h) during 10 days for urinary tract infection. A study on the effect of nitroxoline against the fecal flora is undertaken in a group of 21 children who receive nitroxoline during 4 days or a long period. Bacteriological and clinical efficacy is checked when urinary concentrations of nitroxoline are greater than 16 mg/l. The results show 8 clinical and bacteriological success one true failure and 3 failure due to a non-compliance to the treatment. No qualitative and quantitative modification of the fecal flora is observed after treatment with nitroxoline.
12名儿童（平均年龄：4岁）因尿路感染在诊所接受了10天的硝羟喹啉治疗（200毫克/千克/24小时）。在一组21名儿童中进行了一项关于硝羟喹啉对粪便菌群影响的研究，这些儿童接受了4天或更长时间的硝羟喹啉治疗。当尿液中硝羟喹啉浓度大于16毫克/升时，检查细菌学和临床疗效。结果显示8例临床和细菌学成功，1例真正失败，3例因未遵守治疗方案而失败。用硝羟喹啉治疗后未观察到粪便菌群的定性和定量改变。
