Bourlioux P, Botto H, Karam D, Amgar A, Camey M
Laboratoire de Microbiologie, Centre d'Etudes Pharmaceutiques, Chatenay-Malabry.
Pathol Biol (Paris). 1989 May;37(5):451-4.
Nitroxolin or 5-nitro-8-hydroxyquinoline, used in the treatment of acute or recurrent uncomplicated urinary tract infection (UTI), has been investigated to demonstrate inhibitory effect on bacterial adherence to epithelial cells or solid surfaces. Nitroxolin in vitro and in urine inhibits bacterial adherence of E. coli 38 (MS/MS) on HeLa cells and epithelial cells from human bladder mucosa. In the same conditions, norfloxacin has no effect. Nitroxolin (MIC/8) decreases with a statistically significant difference (p less than 0.001) the bacterial attachment to a urinary catheter surface made in siliconated latex. These results justify the performance of a clinical trial in the prophylaxis of recurrent UTI and the outcome of a bacteriuria associated with indwelling or intermittent bladder catheter.
硝羟喹啉或5-硝基-8-羟基喹啉用于治疗急性或复发性单纯性尿路感染（UTI），其对细菌黏附上皮细胞或固体表面的抑制作用已得到研究。硝羟喹啉在体外和尿液中可抑制大肠杆菌38（MS/MS）对HeLa细胞和人膀胱黏膜上皮细胞的黏附。在相同条件下，诺氟沙星无此作用。硝羟喹啉（MIC/8）能使细菌在硅化乳胶制成的导尿管表面的附着量显著降低（p小于0.001）。这些结果证明了开展预防复发性UTI的临床试验以及与留置或间歇性膀胱导尿管相关的菌尿症研究结果的合理性。
