Oliviero L, Perdiz M, Bourlioux P
Laboratoires Debat, Garches, France.
Pathol Biol (Paris). 1990 May;38(5):455-8.
Nitroxolin or 5-nitro-8-hydroxyquinoline, used in the treatment of acute or recurrent uncomplicated urinary tract infection, has been investigated to demonstrate direct inhibitory effect on Escherichia coli adherence to solid surfaces. First of all, influence of growth medium on bacterial adherence was studied. No relation occurs between growth media enhancing production of adhesins and the ability to adhere to solid surfaces. While bacteria are grown on minimal medium, nitroxolin (MIC/16 to MIC/4) can significantly reduce bacterial adherence to urinary catheter of uropathogenic strains of Escherichia coli AL52 and 382. Increasing the concentration of nitroxolin does not proportionally modify this decrease. When growth is realised on LB broth or agar, nitroxolin does not affect bacterial adherence of strain AL52 and higher doses (8 to 32 mg.l-1) are necessary to obtain the same inhibition of adherence of strain 382. Nitroxolin, in certain conditions, can, directly and rapidly, reduce bacterial adherence to solid surfaces.
硝羟喹啉或5-硝基-8-羟基喹啉用于治疗急性或复发性非复杂性尿路感染，已对其进行研究以证明其对大肠杆菌黏附于固体表面具有直接抑制作用。首先，研究了生长培养基对细菌黏附的影响。增强黏附素产生的生长培养基与黏附于固体表面的能力之间不存在关联。当细菌在基本培养基上生长时，硝羟喹啉（MIC/16至MIC/4）可显著降低尿路致病性大肠杆菌AL52和382菌株对导尿管的细菌黏附。增加硝羟喹啉的浓度并不会按比例改变这种降低效果。当在LB肉汤或琼脂上生长时，硝羟喹啉不会影响AL52菌株的细菌黏附，而对于382菌株，需要更高剂量（8至32mg·l-1）才能获得相同的黏附抑制效果。在某些条件下，硝羟喹啉可直接且迅速地降低细菌对固体表面的黏附。
