围产期疾病严重程度对神经发育的不良影响部分是通过极早产儿出生时早期大脑异常来介导的。
Adverse effects of perinatal illness severity on neurodevelopment are partially mediated by early brain abnormalities in infants born very preterm.
机构信息
Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Biostatistics Resource at Nationwide Children's Hospital, Nationwide Children's Hospital, Columbus, OH, USA.
出版信息
J Perinatol. 2021 Mar;41(3):519-527. doi: 10.1038/s41372-020-00854-1. Epub 2020 Oct 7.
BACKGROUND
We sought to determine the mediating effects of magnetic resonance imaging (MRI) biomarkers at term gestation on the relationship between perinatal illness severity and neurodevelopment.
METHODS
The Clinical Risk Index for Babies-second edition (CRIB-II) was correlated with indices of brain maturation or injury and neurodevelopment at 2-year follow-up in infants born less than 32 weeks gestation. Using a counterfactual mediation analysis, associations between CRIB-II, MRI biomarkers, and neurodevelopment were confirmed, followed by an assessment of the mediating effects of MRI biomarkers on the relationship between CRIB-II and neurodevelopment.
RESULTS
CRIB-II correlated significantly with neurodevelopment and MRI biomarkers of brain injury or cortical maturation. Two MRI biomarkers, cortical surface area and global injury score, were associated with neurodevelopmental scores at follow-up and included in mediation analyses.
CONCLUSION
Biomarkers of cortical maturation or brain injury at term-equivalent age mediated a substantial portion of the risks conveyed by perinatal illness severity on neurodevelopmental outcomes at 2 years corrected age.
背景
我们旨在确定足月妊娠时磁共振成像（MRI）生物标志物在围产期疾病严重程度与神经发育之间的中介作用。
方法
在随访 2 年时，将临床风险指数（CRIB-II）与小于 32 周妊娠出生婴儿的脑成熟或损伤指数以及神经发育相关联。使用反事实中介分析，确认 CRIB-II、MRI 生物标志物和神经发育之间的关联，然后评估 MRI 生物标志物对 CRIB-II 与神经发育之间关系的中介作用。
结果
CRIB-II 与神经发育和脑损伤或皮质成熟的 MRI 生物标志物显著相关。皮质表面积和整体损伤评分这两个 MRI 生物标志物与随访时的神经发育评分相关，并纳入了中介分析。
结论
皮质成熟或脑损伤的生物标志物在足月时，对纠正年龄 2 年时的神经发育结局，中介了围产期疾病严重程度带来的相当一部分风险。
Zotero 插件