Dorman T
J Int Med Res. 1977;5(3):191-4. doi: 10.1177/030006057700500308.
A double-blind between-group trial was carried out in 50 depressed patients to compare the efficacy of two sustained release forms of amitriptyline--Lentizol and Tryptizol 75. Patients received either Lentizol 50 mg or Tryptizol 75 75 mg each evening for the first week of the trial, and these dosages were then doubled for a further four-week trial period, with the proviso that dosage for individual patients could be maintained at, or altered to, original level where considered necessary by the investigator. Lentizol gave equivalent therapeutic effect to Tryptizol 75 despite the fact that overall dosage was one-third less than in the case of the latter.
对50名抑郁症患者进行了一项双盲组间试验，以比较两种阿米替林缓释剂型——Lentizol和Tryptizol 75的疗效。在试验的第一周，患者每晚服用50毫克Lentizol或75毫克Tryptizol 75，然后在接下来的四周试验期内将这些剂量加倍，但前提是研究者认为有必要时，个别患者的剂量可以维持在原水平或调整至原水平。尽管Lentizol的总剂量比Tryptizol 75少三分之一，但它产生了与Tryptizol 75相当的治疗效果。
