• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

作为纤维化生物标志物的半乳糖凝集素-3如何改善心房颤动的诊断和预后？

How Can Galectin-3 as a Biomarker of Fibrosis Improve Atrial Fibrillation Diagnosis and Prognosis?

作者信息

da Silveira Maria Mariana Barros Melo, Cabral Joao Victor Batista, Souza Bruno de Melo, Hazime Louis Hussein Patu, Araujo Sara Larissa de Melo, Xavier Amanda Tavares, Mendes Filho Edivaldo Bezerra, Vasconcelos Luydson Richardson da Silva, Sobral Filho Dario Celestino, de Oliveira Dinaldo Cavalcanti

机构信息

Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco (PPGIT/UFPE), Recife, PE, Brazil.

Pernambuco Cardiovascular Emergency Room Teacher Luiz Tavares (PROCAPE/UPE), Recife, PE, Brazil.

出版信息

J Clin Med Res. 2020 Oct;12(10):647-654. doi: 10.14740/jocmr4313. Epub 2020 Sep 21.

DOI:10.14740/jocmr4313
PMID:33029271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7524564/
Abstract

Galectin-3 (Gal-3) is a biomarker of fibrosis that has been associated with atrial remodeling. Acknowledging the presence of a biomarker in patients with atrial fibrillation (AF) can allow for a better clinical treatment. The aim of this study was to assess the association of Gal-3 with atrial fibrosis in patients with AF. This is a systematic review study. From the total number of studies analyzed, 12 demonstrated a relation between atrial fibrosis and Gal-3 in patients with AF and presented statistically significant association values. We conclude that Gal-3 is associated with atrial fibrosis in patients with AF in all types, as well as after the arrhythmia treatment by ablation.

摘要

半乳糖凝集素-3（Gal-3）是一种纤维化生物标志物，与心房重构有关。认识到心房颤动（AF）患者中存在生物标志物有助于更好地进行临床治疗。本研究的目的是评估Gal-3与AF患者心房纤维化之间的关联。这是一项系统评价研究。在所分析的研究总数中，有12项表明AF患者的心房纤维化与Gal-3之间存在关联，并呈现出具有统计学意义的关联值。我们得出结论，Gal-3与所有类型AF患者的心房纤维化有关，也与心律失常消融治疗后的心房纤维化有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd2b/7524564/7b6e89ab53d7/jocmr-12-647-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd2b/7524564/c7119aed86f6/jocmr-12-647-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd2b/7524564/7b6e89ab53d7/jocmr-12-647-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd2b/7524564/c7119aed86f6/jocmr-12-647-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd2b/7524564/7b6e89ab53d7/jocmr-12-647-g002.jpg

相似文献

1
How Can Galectin-3 as a Biomarker of Fibrosis Improve Atrial Fibrillation Diagnosis and Prognosis?作为纤维化生物标志物的半乳糖凝集素-3如何改善心房颤动的诊断和预后？
J Clin Med Res. 2020 Oct;12(10):647-654. doi: 10.14740/jocmr4313. Epub 2020 Sep 21.
2
The change in circulating galectin-3 predicts absence of atrial fibrillation after thoracoscopic surgical ablation.循环半乳糖凝集素-3 的变化可预测胸腔镜手术消融后心房颤动的消失。
Europace. 2018 May 1;20(5):764-771. doi: 10.1093/europace/eux090.
3
Galectin-3 in patients with atrial fibrillation and restored sinus rhythm.心房颤动并恢复窦性节律患者中的半乳糖凝集素-3。
Folia Med (Plovdiv). 2021 Jun 30;63(3):329-336. doi: 10.3897/folmed.63.e55313.
4
The role of galectin-3 in atrial fibrillation.半乳糖凝集素-3 在心房颤动中的作用。
J Mol Med (Berl). 2023 Dec;101(12):1481-1492. doi: 10.1007/s00109-023-02378-5. Epub 2023 Sep 29.
5
Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes.半乳糖凝集素-3调节心房颤动重塑并预测导管消融结果。
JACC Basic Transl Sci. 2016 Apr;1(3):143-154. doi: 10.1016/j.jacbts.2016.03.003.
6
Insights into the Role of Galectin-3 as a Diagnostic and Prognostic Biomarker of Atrial Fibrillation.探讨半乳糖凝集素-3在心房颤动诊断和预后中的作用。
Dis Markers. 2023 Oct 9;2023:2097012. doi: 10.1155/2023/2097012. eCollection 2023.
7
Serum Galectin-3 Levels Predict Recurrences after Ablation of Atrial Fibrillation.血清半乳糖凝集素-3水平可预测心房颤动消融术后的复发情况。
Sci Rep. 2016 Sep 28;6:34357. doi: 10.1038/srep34357.
8
The Association of Serum Galectin-3 Levels with Atrial Electrical and Structural Remodeling.血清半乳糖凝集素-3水平与心房电重构和结构重构的关系
J Cardiovasc Electrophysiol. 2015 Jun;26(6):635-40. doi: 10.1111/jce.12637. Epub 2015 Mar 27.
9
Galectin-3 in Acute Myocardial Infarction Patients with Atrial Fibrillation.半乳糖凝集素-3 在伴发心房颤动的急性心肌梗死患者中的研究
Med Princ Pract. 2019;28(3):284-290. doi: 10.1159/000497611. Epub 2019 Feb 6.
10
Galectin-3 in Atrial Fibrillation: Mechanisms and Therapeutic Implications.半乳糖凝集素-3 在心房颤动中的作用：机制与治疗意义。
Int J Mol Sci. 2018 Mar 25;19(4):976. doi: 10.3390/ijms19040976.

引用本文的文献

1
Insights into the Role of Galectin-3 as a Diagnostic and Prognostic Biomarker of Atrial Fibrillation.探讨半乳糖凝集素-3在心房颤动诊断和预后中的作用。
Dis Markers. 2023 Oct 9;2023:2097012. doi: 10.1155/2023/2097012. eCollection 2023.

本文引用的文献

1
Serum Galectin-3 level and recurrence of atrial fibrillation post-ablation - Systematic review and meta-analysis.血清半乳糖凝集素-3水平与房颤消融术后复发——系统评价与荟萃分析
Indian Pacing Electrophysiol J. 2020 Mar-Apr;20(2):64-69. doi: 10.1016/j.ipej.2020.02.002. Epub 2020 Feb 17.
2
Galectin-3 in Acute Myocardial Infarction Patients with Atrial Fibrillation.半乳糖凝集素-3 在伴发心房颤动的急性心肌梗死患者中的研究
Med Princ Pract. 2019;28(3):284-290. doi: 10.1159/000497611. Epub 2019 Feb 6.
3
Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients.
半乳糖凝集素-3激活成纤维细胞中的TGF-β1/α-SMA/Col I促纤维化途径，导致实验模型和患者的心房纤维化。
Cell Physiol Biochem. 2018;47(2):851-863. doi: 10.1159/000490077. Epub 2018 May 22.
4
Galectin-3 in patients with coronary heart disease and atrial fibrillation.半乳糖凝集素-3 在冠心病合并心房颤动患者中的表达。
Clin Chim Acta. 2018 Mar;478:166-170. doi: 10.1016/j.cca.2017.12.041. Epub 2017 Dec 27.
5
Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease.可溶性生长刺激表达基因 2 蛋白和高敏 C 反应蛋白与冠状动脉疾病患者新发心房颤动的相关性。
Int J Cardiol. 2017 Dec 1;248:173-178. doi: 10.1016/j.ijcard.2017.07.022.
6
Galectin-3 and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study.半乳糖凝集素-3与心房颤动发病率：社区动脉粥样硬化风险（ARIC）研究
Am Heart J. 2017 Oct;192:19-25. doi: 10.1016/j.ahj.2017.07.001. Epub 2017 Jul 8.
7
Executive Summary of the II Brazilian Guidelines for Atrial Fibrillation.《巴西房颤指南（第二版）》执行摘要
Arq Bras Cardiol. 2016 Dec;107(6):501-508. doi: 10.5935/abc.20160190.
8
The change in circulating galectin-3 predicts absence of atrial fibrillation after thoracoscopic surgical ablation.循环半乳糖凝集素-3 的变化可预测胸腔镜手术消融后心房颤动的消失。
Europace. 2018 May 1;20(5):764-771. doi: 10.1093/europace/eux090.
9
Galectin-3 as a marker of interstitial atrial remodelling involved in atrial fibrillation.半乳糖凝集素-3 作为与心房颤动相关的间质心房重构的标志物。
Sci Rep. 2017 Jan 12;7:40378. doi: 10.1038/srep40378.
10
Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?半乳糖凝集素-3：一种检测阵发性心房颤动的生化标志物？
Clin Invest Med. 2016 Dec 1;39(6):27528.