Lewis Catrin, Lewis Katie, Kitchiner Neil, Isaac Samantha, Jones Ian, Bisson Jonathan I
Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Eur J Psychotraumatol. 2020 Jul 9;11(1):1767349. doi: 10.1080/20008198.2020.1767349.
Sleep disturbance has been described as a 'hallmark' symptom of posttraumatic stress disorder (PTSD). Although there are robust findings of self-reported sleep disturbance in PTSD, evidence of sleep disturbance measured using actigraphy is less certain.
To conduct a systematic review and meta-analysis to determine whether there are any significant differences between individuals with and without PTSD in actigraph-derived sleep measures.
Case-control studies comparing participants with current PTSD to those without PTSD were eligible for inclusion. Sleep parameters of interest were: (1) total sleep time; (2) sleep onset latency; (3) wake after sleep onset (WASO); and (4) sleep efficiency. Data were meta-analysed as standardised mean differences (SMDs) and potential sources of heterogeneity were explored through meta-regression. Six actigraphy studies with 405 participants were included.
There was no evidence of a statistically significant difference between those with and without PTSD in total sleep time (SMD 0.09, 95%CI -0.23 to 0.42); WASO (SMD 0.18, 95%CI -0.06 to 0.43); sleep latency (SMD 0.32, 95%CI -0.04 to 0.69); or sleep efficiency (SMD -0.28, 95%CI -0.78 to 0.21).
Further high-quality research is required to determine whether there is a true difference in sleep between those with and without PTSD.
睡眠障碍被描述为创伤后应激障碍（PTSD）的“标志性”症状。尽管在PTSD患者中自我报告的睡眠障碍有确凿的研究结果，但使用活动记录仪测量睡眠障碍的证据尚不明确。
进行系统评价和荟萃分析，以确定PTSD患者和非PTSD患者在活动记录仪得出的睡眠指标上是否存在显著差异。
纳入比较当前患有PTSD的参与者与未患PTSD的参与者的病例对照研究。感兴趣的睡眠参数包括：（1）总睡眠时间；（2）入睡潜伏期；（3）睡眠中觉醒时间（WASO）；（4）睡眠效率。数据以标准化均数差（SMD）进行荟萃分析，并通过荟萃回归探索异质性的潜在来源。纳入了六项有405名参与者的活动记录仪研究。
没有证据表明PTSD患者和非PTSD患者在总睡眠时间（SMD 0.09，95%CI -0.23至0.42）、WASO（SMD 0.18，95%CI -0.06至0.43）、睡眠潜伏期（SMD 0.32，95%CI -0.04至0.69）或睡眠效率（SMD -0.28，95%CI -0.78至0.21）上存在统计学显著差异。
需要进一步的高质量研究来确定PTSD患者和非PTSD患者在睡眠方面是否存在真正差异。
