Neurology Department, Akdeniz University Hospital, B/BLOK 1. Floor. Dumlupınar Bulv. No: 55 07060, Konyaaltı, Antalya, Turkey.
Hematology Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd. 07100, Muratpaşa, Antalya, Turkey.
Sleep Breath. 2021 Jun;25(2):989-994. doi: 10.1007/s11325-020-02185-z. Epub 2020 Oct 8.
To determine the prevalence of poor sleep quality and RLS in adult patients with sickle cell anemia (SCA). The second aim was to identify the risk factors for RLS and impairment of sleep quality in SCA patients.
Patients at least 18 years old, with hemoglobin electrophoresis confirmation of sickle cell disease, were included. Restless legs syndrome was diagnosed according to the International Restless Legs Syndrome Study Group criteria. The sleep quality of the patients was determined using the Pittsburgh Sleep Quality Index (PSQI) scale. The Epworth Sleepiness Scale (ESS) was used to assess excessive daytime sleepiness.
Of 72 patients enrolled in the study, the median total PSQI score was 5 (R 1-17). The total PSQI score was significantly associated with increased age and number of acute severe or extremely severe painful crises during the previous year (p < 0.001, r = 0.45; p = 0.013, r = 0.291 respectively). Of 72 patients, 13 (18%) had RLS and 11 (15%) had excessive daytime sleepiness. The presence of RLS was significantly associated with increased age (p = 0.004). The presence of RLS was not associated with fetal hemoglobin, hemoglobin, hematocrit, or ferritin levels (p > 0.05 for all).
The prevalence of RLS among this sample of adult patients with sickle cell anemia was much higher than that previously reported for the general Turkish population. The presence of RLS was an important cause of sleep disturbance in these adult patients with SCA.
确定成人镰状细胞贫血（SCA）患者睡眠质量差和不宁腿综合征（RLS）的患病率。第二个目的是确定 RLS 和 SCA 患者睡眠质量受损的危险因素。
纳入至少 18 岁、血红蛋白电泳证实为镰状细胞病的患者。根据国际不宁腿综合征研究组标准诊断 RLS。使用匹兹堡睡眠质量指数（PSQI）量表评估患者的睡眠质量。使用 Epworth 嗜睡量表（ESS）评估白天过度嗜睡。
在纳入研究的 72 名患者中，中位 PSQI 总分 5 分（R 1-17）。PSQI 总分与年龄增加和前一年发生的急性严重或极度严重疼痛危象次数呈显著正相关（p<0.001，r=0.45；p=0.013，r=0.291）。72 名患者中，13 名（18%）有 RLS，11 名（15%）有白天过度嗜睡。RLS 的存在与年龄增加显著相关（p=0.004）。RLS 的存在与胎儿血红蛋白、血红蛋白、红细胞压积或铁蛋白水平无关（p>0.05）。
与之前报告的土耳其普通人群相比，该样本中成年 SCA 患者的 RLS 患病率高得多。RLS 的存在是这些成年 SCA 患者睡眠障碍的一个重要原因。
