Baran Rıza Taner, Atar Müge, Pirgon Özgür, Filiz Serkan, Filiz Meral
University of Health Sciences, Antalya Training and Research Hospital, Clinic of Pediatric Endocrinology and Diabetes, Antalya, Turkey
Süleyman Demirel University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Isparta, Turkey
J Clin Res Pediatr Endocrinol. 2018 Jun 1;10(2):131-138. doi: 10.4274/jcrpe.5165. Epub 2017 Nov 24.
Adult epidemiological studies suggest that the rate of Restless Legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and to assess the association with sleep quality and health-related glucose metabolism markers.
The study group comprised 144 obese and overweight children aged 10-16 yearsand the control group consisted of 66 age-matched healthy children. The RLS Questionnaire devised by the International RLS Study and the Pittsburgh Sleep Quality Index (PSQI), where a score >5 indicates poor sleep quality, was used to assess sleep quality.
Mean body mass index (BMI) of the overweight/obese and control groups were 30.5±0.5 and 18.7±0.2, respectively. The frequency of RLS was higher in the obese group (21.7%) than the overweight (3.4%) and control (1.5%) (p<0.001) groups. The frequency of a poor PSQI score was significantly higher (p<0.001) in the obese group (37.3%) than the control group (24.2%). The obese with RLS group also had poorer sleep quality scores than the non-RLS obese group. Many symptoms of sleep disruption were more common in obese patients with RLS and RLS was independently correlated with a high PSQI score [odds ratio (OR): 2.25, confidence interval (Cl): 0.96-5.28, p<0.001)] and an increased BMI z-score (OR: 8.87, Cl: 2.04-38.61, p<0.001).
RLS is common in obese children and may be associated with altered sleep quality. Obese children with RLS need to be assessed since they may need support to improve their sleep quality.
成人流行病学研究表明，普通人群中不宁腿综合征（RLS）的发生率可能在5%至15%之间。本研究的目的是调查10至16岁肥胖青少年社区样本中RLS的频率，并评估其与睡眠质量和健康相关葡萄糖代谢标志物的关联。
研究组包括144名10至16岁的肥胖和超重儿童，对照组由66名年龄匹配的健康儿童组成。采用国际RLS研究设计的RLS问卷和匹兹堡睡眠质量指数（PSQI）（PSQI得分>5表明睡眠质量差）来评估睡眠质量。
超重/肥胖组和对照组的平均体重指数（BMI）分别为30.5±0.5和18.7±0.2。肥胖组RLS的发生率（21.7%）高于超重组（3.4%）和对照组（1.5%）（p<0.001）。肥胖组PSQI得分差的频率（37.3%）显著高于对照组（24.2%）（p<0.001）。患有RLS的肥胖组睡眠质量得分也比未患RLS的肥胖组差。许多睡眠中断症状在患有RLS的肥胖患者中更常见，并且RLS与高PSQI得分[优势比（OR）：2.25，置信区间（Cl）：0.96 - 5.28，p<0.001]和BMI z评分增加（OR：8.87，Cl：2.04 - 38.61，p<0.001）独立相关。
RLS在肥胖儿童中很常见，并且可能与睡眠质量改变有关。患有RLS的肥胖儿童需要接受评估，因为他们可能需要支持来改善睡眠质量。
