因嗅神经母细胞瘤导致的面部毁容：化疗重获美丽。
Facial disfigurement due to olfactory neuroblastoma: beauty regained with chemotherapy.
机构信息
Department of Medical Oncology, Hematology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
出版信息
Cancer Rep (Hoboken). 2021 Feb;4(1):e1303. doi: 10.1002/cnr2.1303. Epub 2020 Oct 8.
BACKGROUND
Olfactory neuroblastoma (ONB) is a sinonasal malignancy seldom seen in clinical practice. It is also known by various other names like esthesioneuroblastoma, esthesioneuroepithelioma, esthesioneurocytoma, and esthesioneuroma. Surgery and radiation therapy are considered as standard treatment modalities for ONB; however, the role of chemotherapy is not well established.
AIMS
We aim to define the role of chemotherapy in the neoadjuvant setting in a case of ONB.
METHODS AND RESULTS
We report a young female patient presenting with a naso-facial swelling causing facial disfigurement, proptosis, decreased visual acuity, and poor performance status. She was diagnosed with advanced-stage ONB. Prompt administration of chemotherapy led to the improvement in the symptoms and rapid regression of the tumor mass. Later on, the tumor mass was excised completely without any neurological deficit.
CONCLUSION
This report justifies the role of neoadjuvant chemotherapy in the management of ONB.
背景
嗅神经母细胞瘤（ONB）是一种在临床实践中很少见的鼻腔鼻窦恶性肿瘤。它还有其他名称，如嗅神经母细胞瘤、嗅神经上皮瘤、嗅神经细胞瘤和嗅神经瘤。手术和放射治疗被认为是 ONB 的标准治疗方法；然而，化疗的作用尚未得到充分确立。
目的
我们旨在确定化疗在 ONB 新辅助治疗中的作用。
方法和结果
我们报告了一例年轻女性患者，因面部肿胀导致面部畸形、眼球突出、视力下降和身体状况不佳而就诊。她被诊断为晚期 ONB。及时给予化疗导致症状改善和肿瘤快速消退。随后，肿瘤完全切除，无神经功能缺损。
结论
本报告证实了新辅助化疗在 ONB 治疗中的作用。
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