Department of Surgery and Orthopedics, School of Medicine of Botucatu, Paulista State University, UNESP, São Paulo, Brazil.
Department of Biostatistics-Biosciences Institute, Paulista State University, UNESP, São Paulo, Brazil.
Phlebology. 2021 May;36(4):303-312. doi: 10.1177/0268355520964293. Epub 2020 Oct 8.
To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears.
Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol-glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy (luminal occlusion), complications (phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology (sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis).
Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis ( = 0.003), 46.15% ulceration ( = 0.003), and 69.2% local inflammation ( < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis ( = 0.03) in the foam group.
Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events.
比较向兔耳背静脉注入硬化剂的疗效和安全性。
将 30 只兔子的 60 只耳朵随机分配到以下组别：1%液体聚多卡醇、1%聚多卡醇泡沫、0.2%聚多卡醇-70%葡萄糖溶液、75%葡萄糖或 0.9%生理盐水。结果包括疗效（管腔闭塞）、并发症（静脉炎、新生血管形成、穿刺部位溃疡、坏死和局部炎症）和组织学（硬化、再通静脉和周围组织炎症、血液外渗、再通、淋巴管生成、软骨破坏和新生血管形成）。
泡沫组的硬化效果较好（76.9%），但坏死率也较高（30.7%）（=0.003），溃疡率（46.15%）（=0.003）和局部炎症率（69.2%）（<0.0001）较高。新生血管形成率相似。组织学显示泡沫组静脉炎（38.5%）（p=0.004）和坏死（38.5%）（=0.03）的发生率较高。
与其他组相比，泡沫和液体聚多卡醇的硬化效果较好，但特别是聚多卡醇泡沫会导致更多的不良反应。
