Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva str., 13, 614081 Perm, Russia.
Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva str., 13, 614081 Perm, Russia.
J Neuroimmunol. 2020 Dec 15;349:577421. doi: 10.1016/j.jneuroim.2020.577421. Epub 2020 Sep 30.
The effect of pregnancy hormone estriol (E) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E influence. At the same time, E stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients. Thus, the MS amelioration during pregnancy may be related to E influence.
研究了妊娠激素雌三醇（E）对多发性硬化症（MS）患者与健康供体（HD）的固有和适应性免疫细胞功能的影响。E 抑制了中性粒细胞的吞噬活性，并增强了单核细胞的 IDO 活性。E 的影响下，Treg 细胞的比例增加，Th17 和 iNKT 细胞的数量减少。同时，E 刺激了 IL-10 的产生并抑制了 IL-17 的分泌。这些激素作用在 HD 和 MS 患者的细胞上均得到了体现。因此，妊娠期间 MS 的改善可能与 E 的影响有关。
