Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Metab Brain Dis. 2023 Mar;38(3):739-747. doi: 10.1007/s11011-022-01138-7. Epub 2023 Jan 3.
Hormonal imbalance may be an important factor in the severity of multiple sclerosis (MS) disease. In this context, hormone therapy has been shown to have immunoregulatory potential in various experimental approaches. There is increasing evidence of potentially beneficial effects of thyroid, melatonin, and sex hormones in MS models. These hormones may ameliorate the neurological impairment through immunoregulatory and neuroprotective effects, as well as by reducing oxidative stress. Expanding our knowledge of hormone therapy may be an effective step toward identifying additional molecular/cellular pathways in MS disease. In this review, we discuss the role of several important hormones in MS pathogenesis in terms of their effects on immunoregulatory aspects and neuroprotection.
激素失衡可能是多发性硬化症 (MS) 疾病严重程度的一个重要因素。在这方面，激素疗法已被证明在各种实验方法中具有免疫调节潜力。越来越多的证据表明甲状腺、褪黑素和性激素对 MS 模型有潜在的有益作用。这些激素可能通过免疫调节和神经保护作用以及减轻氧化应激来改善神经功能障碍。扩大我们对激素疗法的认识可能是确定 MS 疾病中其他分子/细胞途径的有效步骤。在这篇综述中，我们根据激素对免疫调节方面和神经保护的影响来讨论几种重要激素在 MS 发病机制中的作用。
