Universidad Católica de Colombia, Faculty of Psychology, GAEM Group (Research methods applied to behavioral sciences), Bogotá, Colombia.
Universidad de Santander, Faculty of Health Sciences, medicine program, Neurosciences Research Group, Bucaramanga, Colombia.
J Affect Disord. 2021 Jan 1;278:576-582. doi: 10.1016/j.jad.2020.09.096. Epub 2020 Sep 29.
The PHQ-2 is a screening test for major depressive disorder (MDD) derived from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in previous studies. The psychometric properties of PHQ-2 in the Colombian population are unknown.
PHQ-2 were assessed in 243 patients in general medical consultations using the Mini-International Neuropsychiatric Interview (MINI) as the gold standard. Internal consistency, convergent validity and criterion validity were calculated by analyzing the Receptor Operating Characteristics (ROC) and the area under the curve (AUC).
Cronbach's alpha and McDonald's omega coefficients were 0.71. Spearman's rho coefficients for correlations with PHQ-9 and HADS-D scores were 0.63 and 0.59 (p<0.01). AUC was 0.89. The optimal cut point was ≥2 with the following indicators: sensitivity 0.87 specificity 0.74; Youden index 0.60; PPV 0.47; NPV 0.95; (LR+) 3.24; (LR-) 0.18 (95% CI 0.09-0.37). Kappa coefficient between PHQ-2 and MINI for depression was .458 and 0.46 for HADS-D.
Since this study was done with people attending hospital, which could has implications for the prevalence of depression, affecting the validity indicators of the instrument.
PHQ-2 show an acceptable test performance in the context of the study. However, the test could yield a considerable amount of false positives that would require specialized evaluation to establish a reliable diagnosis.
PHQ-2 是从 PHQ-9 衍生而来的用于筛查重度抑郁症（MDD）的筛选测试，在之前的研究中已证明其在检测具有临床意义的病例方面有用。PHQ-2 在哥伦比亚人群中的心理测量特性尚不清楚。
使用 Mini-国际神经精神访谈（MINI）作为金标准，在普通医疗咨询中对 243 例患者进行 PHQ-2 评估。通过分析受体操作特征（ROC）和曲线下面积（AUC）来计算内部一致性、收敛效度和标准效度。
克朗巴赫的 α 和麦克唐纳的 ω 系数分别为 0.71。与 PHQ-9 和 HADS-D 评分的 Spearman rho 系数分别为 0.63 和 0.59（p<0.01）。AUC 为 0.89。最佳截断点为≥2，以下指标为：敏感性 0.87 特异性 0.74；约登指数 0.60；PPV 0.47；NPV 0.95；（LR+）3.24；（LR-）0.18（95%CI 0.09-0.37）。PHQ-2 与 MINI 之间的抑郁诊断的 Kappa 系数为.458，HADS-D 为 0.46。
由于这项研究是在医院就诊的人群中进行的，这可能会对抑郁的流行率产生影响，从而影响仪器的有效性指标。
PHQ-2 在研究背景下表现出可接受的测试性能。但是，该测试可能会产生相当数量的假阳性，需要进行专门的评估才能建立可靠的诊断。
