Altmannsberger M, Dirk T, Osborn M, Weber K
Semin Diagn Pathol. 1986 Nov;3(4):306-16.
There is abundant evidence that intermediate filaments can be used as cell type specific markers both for normal tissue and for tumors. The results of intermediate filament typing in soft tissue tumors and its diagnostic relevance is shown. This system can also be used to solve other problems in surgical pathology. One of the most useful applications of intermediate filament typing is to differentiate the round cell tumors of children; thus, rhabdomyo-sarcomas are desmin positive, malignant lymphomas contain only vimentin, and neuroblastomas show positivity for neurofilaments.
有充分证据表明，中间丝可作为正常组织和肿瘤的细胞类型特异性标志物。展示了软组织肿瘤中中间丝分型的结果及其诊断意义。该系统还可用于解决外科病理学中的其他问题。中间丝分型最有用的应用之一是鉴别儿童的圆形细胞肿瘤；因此，横纹肌肉瘤结蛋白呈阳性，恶性淋巴瘤仅含有波形蛋白，而成神经细胞瘤神经丝呈阳性。
