Ruutu P, Valtonen V, Tiitanen L, Elonen E, Volin L, Veijalainen P, Ruutu T
Scand J Infect Dis. 1987;19(3):347-51. doi: 10.3109/00365548709018481.
Within a period of 15 months 8 cases of invasive pulmonary aspergillosis were seen in a haematologic unit; 7 of them between January and October 1984. No previous cases of invasive aspergillosis had been encountered during the existence of the unit since 1979. Environmental studies did not prove a single likely source for the fungal spores. Previous window renovation with concomitant fiber deposits on ventilation grids, poor sealing of air filter fittings in patient rooms, occasional ventilation through windows in the ward, and low speed of booster fans in the ventilation system may have created a condition favourable for the entry of Aspergillus fumigatus spores into the patient rooms. Environmental sanitation including cleaning of the ventilation ducts and change of filters in the ventilation system stopped the outbreak. Two sporadic cases have appeared during a follow-up period of 26 months.
在15个月的时间里，血液科出现了8例侵袭性肺曲霉病；其中7例发生在1984年1月至10月期间。自1979年该科室成立以来，此前从未遇到过侵袭性曲霉病病例。环境研究未证实真菌孢子有单一可能来源。此前的窗户翻新以及通风格栅上随之产生的纤维沉积物、病房空气过滤器配件密封不良、病房偶尔通过窗户通风以及通风系统中增压风扇速度较低，可能创造了有利于烟曲霉孢子进入病房的条件。包括清洁通风管道和更换通风系统过滤器在内的环境卫生措施制止了疫情爆发。在26个月的随访期内出现了2例散发病例。
