Rył Aleksandra, Rotter Iwona, Szylińska Aleksandra, Jurewicz Alina, Bohatyrewicz Andrzej, Miazgowski Tomasz
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Department of Orthopaedics Traumatology and Musculoskeletal Oncology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Aging (Albany NY). 2020 Oct 9;12(19):19539-19545. doi: 10.18632/aging.103903.
It has been suggested that visceral fat (VF) might be a negative determinant of bone health. The purpose of this cross-sectional study was to assess an interplay among fat, visceral fat (VF), muscle mass, bone mineral density (BMD), and markers of bone turnover in men aged 60-75 years. BMD, lean mass, total fat, VF and appendicular skeletal muscle mass (ASM) were assessed using dual-energy X-ray absorptiometry. Using ELISA assays, we measured serum levels of markers of bone turnover (osteocalcin, parathyroid hormone, human procollagen I N-terminal peptide, and degradation products of C-terminal telopeptide of type I collagen). Mean values of bone markers were within normal range. VF was found not to be associated with BMD and bone turnover markers. ASM was inversely correlated with age, and positively with BMD and lean mass. In linear regression, ASM, VF, total fat, lean mass and body mass index were significant single predictors of BMD. However, after adjustment for age, all these associations were no longer significant. In conclusion, in contrast to some studies on postmenopausal women, in older non-diabetic men with normal lean mass and body fat VF was not associated with BMD and markers of bone formation and resorption.
有人提出，内脏脂肪（VF）可能是骨骼健康的一个负面决定因素。这项横断面研究的目的是评估60 - 75岁男性中脂肪、内脏脂肪（VF）、肌肉量、骨矿物质密度（BMD）和骨转换标志物之间的相互作用。使用双能X线吸收法评估骨矿物质密度、瘦体重、总脂肪、内脏脂肪和附属骨骼肌量（ASM）。通过酶联免疫吸附测定法，我们测量了骨转换标志物（骨钙素、甲状旁腺激素、人I型前胶原N端肽和I型胶原C端肽降解产物）的血清水平。骨标志物的平均值在正常范围内。发现内脏脂肪与骨矿物质密度和骨转换标志物无关。附属骨骼肌量与年龄呈负相关，与骨矿物质密度和瘦体重呈正相关。在线性回归中，附属骨骼肌量、内脏脂肪、总脂肪、瘦体重和体重指数是骨矿物质密度的显著单一预测因子。然而，在调整年龄后，所有这些关联不再显著。总之，与一些关于绝经后女性的研究不同，在瘦体重和体脂正常的老年非糖尿病男性中，内脏脂肪与骨矿物质密度以及骨形成和吸收标志物无关。
