Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Obesity Unit, Centro de Pesquisa Clínica Multiusuário (CePeM), Hospital Universitário Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Trials. 2022 Sep 2;23(1):733. doi: 10.1186/s13063-022-06677-z.
Evidence of the benefits induced from resistance exercise on health markers of post-bariatric patients is limited. The study will investigate the effects of a resistance training (RT) program on muscle mass and strength, bone metabolism biomarkers, bone mineral density (BMD), bone microarchitecture, and endothelial function of patients subjected to Roux-en-Y gastric bypass.
METHODS/DESIGN: This randomized controlled trial will include 60 post-bariatric patients, physically inactive, aging 18 to 50 years, with a post-surgery period ≥ 12 months. They will be randomly assigned into two groups: (i) the non-exercised control group, which will receive the standard clinical follow-up, or (ii) the intervention group which will consist of RT (60 min/session; 3 times/week, for 6 months). The primary outcomes will include muscle mass and strength, bone metabolism biomarkers, BMD, and bone microarchitecture. The secondary outcomes will be anthropometry, hemodynamic measurements, cardiovascular risk factors, health-related quality of life (QoL), and endothelial function. Outcomes will be assessed by blood biomarkers of bone formation and reabsorption, dual X-ray absorptiometry, repetition maximum and handgrip strength tests, high-resolution peripheral quantitative computed tomography, 36-Item Short-Form Health Survey, venous occlusion plethysmography, and nailfold videocapillaroscopy.
It is expected that there are greater benefits from the RT program, possibly improving muscle mass and strength, bone metabolism, density and microarchitecture, QoL, and cardiovascular risk.
ClinicalTrials.gov NCT04193397. Registered on 7 December 2019.
关于抗阻运动对减重术后患者健康标志物影响的证据有限。本研究将调查一项抗阻训练（RT）计划对接受 Roux-en-Y 胃旁路手术的患者的肌肉质量和力量、骨代谢生物标志物、骨密度（BMD）、骨微结构和内皮功能的影响。
方法/设计：这是一项随机对照试验，将纳入 60 名身体活动不足、年龄在 18 至 50 岁、术后时间≥12 个月的减重术后患者。他们将被随机分为两组：（i）非锻炼对照组，将接受标准临床随访，或（ii）干预组，包括 RT（60 分钟/次；每周 3 次，持续 6 个月）。主要结局将包括肌肉质量和力量、骨代谢生物标志物、BMD 和骨微结构。次要结局将包括人体测量、血液动力学测量、心血管危险因素、健康相关生活质量（QoL）和内皮功能。通过骨形成和吸收的血液生物标志物、双能 X 线吸收法、重复最大力量和握力测试、高分辨率外周定量计算机断层扫描、36 项简短健康调查问卷、静脉闭塞容积描记法和甲襞微血管镜检查来评估结果。
预计 RT 计划会带来更大的益处，可能会改善肌肉质量和力量、骨代谢、密度和微结构、QoL 和心血管风险。
ClinicalTrials.gov NCT04193397. 于 2019 年 12 月 7 日注册。
