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季节性和先前伐木对野生狐猴粪便中寄生虫-微生物群关联的影响。

Effects of seasonality and previous logging on faecal helminth-microbiota associations in wild lemurs.

机构信息

Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

Wildlife Ecology and Conservation Group, Wageningen University & Research, Droevendaalsesteeg 3a, 6708 PB, Wageningen, The Netherlands.

出版信息

Sci Rep. 2020 Oct 8;10(1):16818. doi: 10.1038/s41598-020-73827-1.

DOI:10.1038/s41598-020-73827-1
PMID:33033341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7544911/
Abstract

Gastrointestinal helminth-microbiota associations are shaped by various ecological processes. The effect of the ecological context of the host on the bacterial microbiome and gastrointestinal helminth parasites has been tested in a number of ecosystems and experimentally. This study takes the important step to look at these two groups at the same time and to start to examine how these communities interact in a changing host environment. Fresh faecal samples (N = 335) from eight wild Eulemur populations were collected over 2 years across Madagascar. We used 16S ribosomal RNA gene sequencing to characterise the bacterial microbiota composition, and faecal flotation to isolate and morphologically identify nematode eggs. Infections with nematodes of the genera Callistoura and Lemuricola occurred in all lemur populations. Seasonality significantly contributed to the observed variation in microbiota composition, especially in the dry deciduous forest. Microbial richness and Lemuricola spp. infection prevalence were highest in a previously intensely logged site, whereas Callistoura spp. showed no such pattern. In addition, we observed significant correlations between gastrointestinal parasites and bacterial microbiota composition in these lemurs, with 0.4-0.7% of the variation in faecal bacterial microbiota composition being explained by helminth infections. With this study, we show effects of environmental conditions on gastrointestinal nematodes and bacterial interactions in wild lemurs and believe it is essential to consider the potential role of microbiome-parasite associations on the hosts' GI stability, health, and survival.

摘要

胃肠道寄生虫与微生物群的关联受多种生态过程的影响。宿主生态环境对细菌微生物群和胃肠道寄生虫的影响已在多个生态系统中进行了测试和实验。本研究同时关注这两组，并开始研究这些群落如何在宿主环境变化时相互作用，这是一个重要的进展。本研究在过去 2 年中，从马达加斯加的 8 个野生狐猴种群中收集了 335 份新鲜粪便样本。我们使用 16S 核糖体 RNA 基因测序来描述细菌微生物群组成，并通过粪便浮选分离和形态学鉴定线虫卵。在所有狐猴种群中都发现了 Callistoura 和 Lemuricola 属的线虫感染。季节性显著导致了微生物群组成的观察到的变化，尤其是在旱落叶林中。在之前强烈伐木的地点，微生物丰富度和 Lemuricola spp.感染率最高，而 Callistoura spp.则没有这种模式。此外，我们还观察到这些狐猴的胃肠道寄生虫与细菌微生物群组成之间存在显著相关性，粪便细菌微生物群组成的变化中有 0.4-0.7%可以用寄生虫感染来解释。通过这项研究，我们展示了环境条件对野生狐猴胃肠道线虫和细菌相互作用的影响，并认为有必要考虑微生物群-寄生虫关联对宿主胃肠道稳定性、健康和生存的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/8ade2aa5fb93/41598_2020_73827_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/5a752fea09af/41598_2020_73827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/67e65f721b53/41598_2020_73827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/63eb4fac197b/41598_2020_73827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/92edb48767aa/41598_2020_73827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/310f6046bab0/41598_2020_73827_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/8ade2aa5fb93/41598_2020_73827_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/5a752fea09af/41598_2020_73827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/67e65f721b53/41598_2020_73827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/63eb4fac197b/41598_2020_73827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/92edb48767aa/41598_2020_73827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/310f6046bab0/41598_2020_73827_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bb/7544911/8ade2aa5fb93/41598_2020_73827_Fig7_HTML.jpg

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