气象因素是否会影响急性主动脉夹层的发生？一项 10 年回顾性机构研究。
Do meteorological factors influence the occurrence of acute aortic dissection? A 10-year retrospective institutional study.
机构信息
Division of Cardiac Surgery, Toyota Memorial Hospital, Rena usui 1-1, Heiwa-cho, Toyota, Aichi, 471-8513, Japan.
Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Rena usui 1-1, Heiwa-cho, Toyota, Aichi, 471-8513, Japan.
出版信息
Gen Thorac Cardiovasc Surg. 2021 Apr;69(4):654-661. doi: 10.1007/s11748-020-01498-w. Epub 2020 Oct 8.
OBJECTIVE
This study aimed to clarify the relationship between meteorological factors and the occurrence of aortic dissection.
METHODS
The study included 282 consecutive patients who were admitted to our institute with acute aortic dissection over a 10-year period. The local meteorological data over the same period were analyzed.
RESULTS
On the days with occurrences of acute aortic dissection, there were significant differences in the following factors: the minimum and maximum temperature (p < 0.0001), difference in the minimum and maximum temperature from the 10-year average, atmospheric pressure (p < 0.0001), and difference in atmospheric pressure between the day of occurrence and the previous day. Cut-off values were determined by ROC curve analysis. Univariate analyses identified the following factors as significant predictors of the occurrence of acute aortic dissection: minimum temperature < 4.0 °C (OR 2.42, p < 0.0001), maximum temperature < 15.1 °C (OR 2.23, p < 0.0001), atmospheric pressure > 1008.9 hPa (OR 1.75, p < 0.0001), difference between the minimum temperature and 10-year average < 0.3 °C, difference between the maximum temperature and 10-year average < 0.44 °C; and the difference in atmospheric pressure between the day of occurrence and the previous day > 0.4 hPa. However, the differences of the minimum and maximum temperatures from the 10-year average were the only factors that remained significant in the multivariate analysis. The minimum (R = 0.3055) and maximum temperatures (R = 0.4151) were weakly and moderately correlated, respectively, with the occurrence of acute aortic dissection.
CONCLUSION
Meteorological factors influenced the occurrence of acute aortic dissection. In particular, a minimum temperature of < 4 °C and maximum temperature difference from the 10-year average < 0.44 °C was identified as strong risk factors for the occurrence of acute aortic dissection.
目的
本研究旨在阐明气象因素与主动脉夹层发生之间的关系。
方法
本研究纳入了在我院接受治疗的 282 例急性主动脉夹层患者，研究时间为 10 年。同期分析当地气象数据。
结果
主动脉夹层发生日与无事件日相比，在最低气温、最高气温（p<0.0001）、最低气温与 10 年平均值之差、最高气温与 10 年平均值之差、大气压（p<0.0001）、发生日与前一日大气压之差等气象因素方面存在显著差异。通过 ROC 曲线分析确定了截断值。单因素分析确定了以下因素是急性主动脉夹层发生的显著预测因素：最低气温<4.0℃（OR 2.42，p<0.0001）、最高气温<15.1℃（OR 2.23，p<0.0001）、大气压>1008.9 hPa（OR 1.75，p<0.0001）、最低气温与 10 年平均值之差<0.3℃、最高气温与 10 年平均值之差<0.44℃、发生日与前一日大气压之差>0.4 hPa。然而，在多因素分析中，仅最低气温与 10 年平均值之差和最高气温与 10 年平均值之差是显著的因素。最低气温（R=0.3055）和最高气温（R=0.4151）与急性主动脉夹层的发生分别呈弱相关和中度相关。
结论
气象因素影响急性主动脉夹层的发生。特别是，最低气温<4℃和最高气温与 10 年平均值之差<0.44℃是急性主动脉夹层发生的强危险因素。
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