Ito Kayoko, Inoue Makoto, Nishii Hisae, Matsumoto Tetsuro
Oral Rehabilitation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Division of Dysphagia Rehabilitation, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Low Urin Tract Symptoms. 2021 Apr;13(2):224-229. doi: 10.1111/luts.12354. Epub 2020 Oct 8.
Overactive bladder (OAB) occurs idiopathic or secondary to a neurological cause. In addition, OAB may also occur due to xerostomia, because it causes excessive drinking of water. If xerostomia is one of the causes of OAB, treating xerostomia may be effective. This study aimed to investigate the prevalence of xerostomia with or without overactive bladder symptoms. A web-based questionnaire was administered to investigate the prevalence of xerostomia with or without overactive bladder symptoms. The survey included questions concerning age, gender, medical history, medications, OAB symptoms by the Overactive Bladder Symptom Score (OABSS), and xerostomia by the Dry Mouth Scale (DMS). From the analysis, a total of 21 (13.0%) participants were identified as having OAB. The prevalence of xerostomia was six (28.6%) in the OAB group and 14 (10.0%) in the non-OAB group. OABSS and DMS were significantly higher in the OAB group than in the non-OAB group. Urgency score and urgency incontinence score of OABSS were substantially higher in xerostomia participants than non-xerostomia participants. The adjusted odds ratio of OAB showed DMS total score, xerostomia symptoms, accompanying symptoms, and other symptoms that were all significantly associated with OAB. These results suggested that OAB subjects, even untreated subjects, had xerostomia. It may be beneficial for clinicians to perform dry mouth management in parallel with careful choice pharmacotherapy for the wellness of OAB patients.
膀胱过度活动症（OAB）可特发性出现，也可继发于神经学病因。此外，OAB也可能因口干症而发生，因为口干症会导致过度饮水。如果口干症是OAB的病因之一，治疗口干症可能会有效果。本研究旨在调查有或无膀胱过度活动症状的口干症患病率。通过网络问卷来调查有或无膀胱过度活动症状的口干症患病率。该调查包括有关年龄、性别、病史、用药情况、采用膀胱过度活动症症状评分（OABSS）评估的OAB症状以及采用口干量表（DMS）评估的口干症等问题。经分析，共有21名（13.0%）参与者被确定患有OAB。OAB组中口干症的患病率为6名（28.6%），非OAB组为14名（10.0%）。OAB组的OABSS和DMS显著高于非OAB组。口干症参与者的OABSS尿急评分和急迫性尿失禁评分显著高于非口干症参与者。OAB的调整优势比显示，DMS总分、口干症症状、伴随症状和其他症状均与OAB显著相关。这些结果表明，OAB患者，即使是未经治疗的患者，也存在口干症。对于临床医生而言，在为OAB患者选择合适药物治疗的同时并行口干管理，可能对患者健康有益。
