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本文引用的文献

1
Time-to-event analyses of lower-limb venous thromboembolism in aged patients undergoing lumbar spine surgery: a retrospective study of 1620 patients.老年腰椎手术患者下肢静脉血栓栓塞症的事件发生时间分析:一项对1620例患者的回顾性研究
Aging (Albany NY). 2019 Oct 15;11(19):8701-8709. doi: 10.18632/aging.102364.
2
Predictors of Hospital-Acquired Conditions Are Predominately Similar for Spine Surgery and Other Common Elective Surgical Procedures, With Some Key Exceptions.脊柱手术和其他常见择期手术中,医院获得性疾病的预测因素大体相似,但存在一些关键例外情况。
Global Spine J. 2019 Oct;9(7):717-723. doi: 10.1177/2192568219826083. Epub 2019 Feb 5.
3
D-dimer predicts pulmonary embolism after low-risk spine surgery.D-二聚体可预测低风险脊柱手术后的肺栓塞。
Spine Surg Relat Res. 2018 Feb 28;2(2):113-120. doi: 10.22603/ssrr.2017-0054. eCollection 2018.
4
Venous Thromboembolism Prophylaxis for Patients Having Elective Spine Surgery: When, Why, and How Much.择期脊柱手术患者的静脉血栓栓塞预防:时机、原因及剂量
J Bone Joint Surg Am. 2019 Jul 3;101(13):1220-1229. doi: 10.2106/JBJS.18.00849.
5
Risk Factors for Postoperative Venous Thromboembolic Events in Patients Undergoing Lumbar Spine Surgery.腰椎手术患者术后静脉血栓栓塞事件的危险因素
Global Spine J. 2019 Jun;9(4):409-416. doi: 10.1177/2192568218797094. Epub 2018 Aug 29.
6
Venous Thromboembolism After Degenerative Spine Surgery: A Nationwide Readmissions Database Analysis.退行性脊柱手术后的静脉血栓栓塞:一项全国再入院数据库分析
World Neurosurg. 2019 May;125:e165-e174. doi: 10.1016/j.wneu.2019.01.029. Epub 2019 Jan 23.
7
[Differential expression of exosomal miRNAs in osteoblasts in osteoarthritis].[骨关节炎中成骨细胞中外泌体微小RNA的差异表达]
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Dec 28;43(12):1294-1300. doi: 10.11817/j.issn.1672-7347.2018.12.003.
8
The Rate of Venous Thromboembolism Before and After Spine Surgery as Determined with Indirect Multidetector CT.通过间接多层螺旋CT测定脊柱手术前后静脉血栓栓塞的发生率
JB JS Open Access. 2018 Aug 15;3(3):e0015. doi: 10.2106/JBJS.OA.18.00015. eCollection 2018 Sep 25.
9
D-dimer monitoring combined with ultrasonography improves screening for asymptomatic venous thromboembolism in acute spinal cord injury.D-二聚体监测联合超声检查提高急性脊髓损伤无症状静脉血栓栓塞症的筛查率。
J Spinal Cord Med. 2020 May;43(3):353-357. doi: 10.1080/10790268.2018.1518765. Epub 2018 Sep 10.
10
Thromboembolic risk after lumbar spine surgery: a cohort study on 325 000 French patients.腰椎手术后的血栓栓塞风险:一项针对325000名法国患者的队列研究。
J Thromb Haemost. 2018 Aug;16(8):1537-1545. doi: 10.1111/jth.14205. Epub 2018 Jul 10.

择期脊柱手术中的静脉血栓栓塞预防

Venous Thromboembolism Prophylaxis in Elective Spine Surgery.

作者信息

Solaru Samantha, Alluri Ram K, Wang Jeffrey C, Hah Raymond J

机构信息

5116University of Southern California, Los Angeles, CA, USA.

yKeck School of Medicine of the University of Southern California, Orthopaedic Surgery, CA, USA.

出版信息

Global Spine J. 2021 Sep;11(7):1148-1155. doi: 10.1177/2192568220962439. Epub 2020 Oct 9.

DOI:10.1177/2192568220962439
PMID:33034229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8351068/
Abstract

STUDY DESIGN

Review.

OBJECTIVE

Venothromboembolic (VTE) complications, composed of deep vein thrombosis and pulmonary embolism are commonly observed in the perioperative setting. There are approximately 500 000 postoperative VTE cases annually in the United States and orthopedic procedures contribute significantly to this incidence. Data on the use of VTE prophylaxis in elective spinal surgery is sparse. This review aims to provide an updated consensus within the literature defining the risk factors, diagnosis, and the safety profile of routine use of pharmacological prophylaxis for VTE in elective spine surgery patients.

METHODS

A comprehensive review of the literature and compilation of findings relating to current identified risk factors for VTE, diagnostic methods, and prophylactic intervention and safety in elective spine surgery.

RESULTS

VTE prophylaxis use is still widely contested in elective spine surgery patients. The outlined benefits of mechanical prophylaxis compared with chemical prophylaxis varies among practitioners.

CONCLUSION

The benefits of any form of VTE prophylaxis continues to remain a controversial topic in the elective spine surgery setting. A specific set of guidelines for implementing prophylaxis is yet to be determined. As more risk factors for thromboembolic events are identified, the complexity surrounding intervention selection increases. The benefits of prophylaxis must also continue to be balanced against the increased risk of bleeding events and neurologic injury.

摘要

研究设计

综述。

目的

静脉血栓栓塞(VTE)并发症,包括深静脉血栓形成和肺栓塞,在围手术期很常见。在美国,每年约有50万例术后VTE病例,骨科手术在这一发病率中占很大比例。关于择期脊柱手术中VTE预防措施使用的数据很少。本综述旨在提供文献中的最新共识,以确定择期脊柱手术患者常规使用药物预防VTE的风险因素、诊断方法和安全性。

方法

全面回顾文献,并汇总与当前已确定的择期脊柱手术中VTE风险因素、诊断方法以及预防性干预和安全性相关的研究结果。

结果

在择期脊柱手术患者中,VTE预防措施的使用仍存在广泛争议。与化学预防相比,机械预防的既定益处因从业者而异。

结论

在择期脊柱手术中,任何形式的VTE预防措施的益处仍然是一个有争议的话题。尚未确定实施预防措施的具体指南。随着更多血栓栓塞事件风险因素的确定,干预选择的复杂性增加。预防措施的益处还必须继续与出血事件和神经损伤风险的增加相权衡。