School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P. R. China.
Chem Commun (Camb). 2020 Nov 11;56(87):13405-13408. doi: 10.1039/d0cc05607c. Epub 2020 Oct 9.
A bimolecular i-motif mediated FRET strategy was developed based on the proximity-induced folding of two identical cytosine-rich DNA strands. This strategy affords a FRET signal that is highly matched to the dimerization event, and enabled accurate and dynamic in situ imaging of Met homodimerization on a living tumor cell surface.
基于两个相同的富含胞嘧啶的 DNA 链的近邻诱导折叠，开发了一种双分子 i-motif 介导的 FRET 策略。该策略提供了与二聚化事件高度匹配的 FRET 信号，能够在活肿瘤细胞表面上准确、动态地进行 Met 同源二聚化的原位成像。
