关于前列腺素E2类似物治疗胃十二指肠溃疡愈合的双盲临床试验。
Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues.
作者信息
Gibiński K, Rybicka J, Mikoś E, Nowak A
出版信息
Gut. 1977 Aug;18(8):636-9. doi: 10.1136/gut.18.8.636.
Abstract
Seventy-seven patients with gastroduodenal ulcer were treated with two methyl-prostaglandin E2 analogues, m-PGE2, in a double-blind clinical trial. Each of three groups was given 15 S-15 methyl PGE2 methyl ester, 15 R-15 methyl PGE2 methyl ester, and placebo, respectively. Both forms of m-PGE2 analogues appeared to reduce gastric acid secretion, to shorten ulcer healing, and also to produce some side-effects, form 'S' being the more potent. Prompt healing of the ulcer with these agents did not prevent the recurrence of the disease. As the serum gastrin response to a meal after m-PGE2 administration was not reduced, this agent seems directly to affect oxynthic cells.
摘要
在一项双盲临床试验中，77例胃十二指肠溃疡患者接受了两种甲基前列腺素E2类似物——m-PGE2的治疗。三组患者分别给予15 - S-15甲基前列腺素E2甲酯、15 - R-15甲基前列腺素E2甲酯和安慰剂。两种形式的m-PGE2类似物似乎都能减少胃酸分泌、缩短溃疡愈合时间，并且还会产生一些副作用，“S”型的效力更强。这些药物使溃疡迅速愈合，但并不能预防疾病复发。由于给予m-PGE2后血清胃泌素对进餐的反应并未降低，因此该药物似乎直接作用于泌酸细胞。
相似文献
1
Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues.关于前列腺素E2类似物治疗胃十二指肠溃疡愈合的双盲临床试验。
Gut. 1977 Aug;18(8):636-9. doi: 10.1136/gut.18.8.636.
2
3
Effect of orally administered 15(R)-15-methyl prostaglandin E2 and/or an anticholinergic drug on meal-induced gastric acid secretion and serum gastrin level in patients with duodenal ulcers.口服15（R）-15-甲基前列腺素E2和/或抗胆碱能药物对十二指肠溃疡患者进餐诱导的胃酸分泌和血清胃泌素水平的影响。
Scand J Gastroenterol. 1979;14(7):813-9. doi: 10.3109/00365527909181409.
4
[Therapy and prevention of peptic lesions by prostaglandins].[前列腺素对消化性溃疡的治疗与预防]
Z Gastroenterol. 1987 Aug;25 Suppl 3:166-74.
5
Methyl-prostaglandin E2 analogues for healing of gastro-duodenal ulcers.用于治疗胃十二指肠溃疡的甲基前列腺素E2类似物
Scand J Gastroenterol. 1978;13(2):155-9. doi: 10.3109/00365527809181742.
6
Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.口服前列腺素E₂及其15-甲基类似物对胃液分泌的影响。
Br Med J. 1973 Jan 20;1(5846):143-6. doi: 10.1136/bmj.1.5846.143.
7
The effect of prostaglandin E2 on duodenal ulcer healing.前列腺素E2对十二指肠溃疡愈合的影响。
Prostaglandins. 1982 Oct;24(4):527-36. doi: 10.1016/0090-6980(82)90010-7.
8
9
Effects of an orally administered prostaglandin analogue (16, 16-dimethyl prostaglandin E2) on human gastric secretion.口服前列腺素类似物（16,16-二甲基前列腺素E2）对人胃液分泌的影响。
Gastroenterology. 1975 Sep;69(3):607-11.
10
The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients.15（R）-15-甲基前列腺素E2对十二指肠溃疡患者进餐刺激的胃酸分泌、血清胃泌素及胰多肽的影响。
Dig Dis Sci. 1979 May;24(5):381-4. doi: 10.1007/BF01297125.
引用本文的文献
1
Wound Healing Effect of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor from Plant.植物来源的15-羟基前列腺素脱氢酶抑制剂的伤口愈合作用
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S122-S126. doi: 10.4103/0973-1296.203971. Epub 2017 Apr 7.
2
Effect of oral 16,16-dimethyl-prostaglandin E2 on basal acid output in man.口服16,16 - 二甲基前列腺素E2对人体基础胃酸分泌量的影响。
Br J Clin Pharmacol. 1982 Mar;13(3):456-7. doi: 10.1111/j.1365-2125.1982.tb01405.x.
3
Oral tripotassium-dicitratobismuthate in gastric and duodenal ulceration. A double-blind controlled trial.枸橼酸铋钾治疗胃及十二指肠溃疡。一项双盲对照试验。
Dig Dis Sci. 1983 Jan;28(1):13-7. doi: 10.1007/BF01393355.
4
Newer antisecretory agents for peptic ulcer.用于消化性溃疡的新型抗分泌药物。
Drugs. 1983 Mar;25(3):315-30. doi: 10.2165/00003495-198325030-00003.
5
New drugs for peptic ulcer.治疗消化性溃疡的新药。
Br Med J. 1980 Jul 12;281(6233):95-6.
6
[Histological and ultrastructural findings in the healing phase of duodenal ulcer].[十二指肠溃疡愈合期的组织学和超微结构研究结果]
Klin Wochenschr. 1985 Oct 15;63(20):1061-70. doi: 10.1007/BF01739674.
7
Therapeutic aspects of prostaglandins in the treatment of peptic ulcer disease.前列腺素在消化性溃疡疾病治疗中的治疗学方面
Dig Dis Sci. 1986 Feb;31(2 Suppl):42S-46S. doi: 10.1007/BF01309322.
8
Interim results of a multicenter international comparison of misoprostol and cimetidine in the treatment of out-patients with benign gastric ulcers.米索前列醇与西咪替丁治疗门诊良性胃溃疡的多中心国际比较的中期结果
Dig Dis Sci. 1985 Nov;30(11 Suppl):178S-184S. doi: 10.1007/BF01309406.
9
A multicenter international controlled comparison of two dosage regimes of misoprostol and cimetidine in the treatment of duodenal ulcer in out-patients.米索前列醇与西咪替丁两种给药方案治疗门诊十二指肠溃疡的多中心国际对照比较
Dig Dis Sci. 1985 Nov;30(11 Suppl):171S-177S. doi: 10.1007/BF01309405.
10
Prostaglandins in pathophysiology of peptic ulcer disease.前列腺素在消化性溃疡疾病病理生理学中的作用
Dig Dis Sci. 1985 Nov;30(11 Suppl):105S-108S. doi: 10.1007/BF01309393.
本文引用的文献
1
Radioimmunoassay of gastrin.胃泌素的放射免疫测定
Gastroenterology. 1970 Jan;58(1):1-14.
2
[Diagnostic value of fiberoduodenoscopy].[纤维十二指肠镜检查的诊断价值]
Przegl Lek. 1974;31(7):663-7.
3
Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man.给人体口服两种前列腺素类似物后，胃分泌受到显著抑制。
Life Sci. 1974 Feb 1;14(3):533-8. doi: 10.1016/0024-3205(74)90367-1.
4
The effect of orally and intravenously administered prostaglandin 16:16 dimethyl E2 methyl ester on human gastric acid secretion.口服和静脉注射前列腺素16:16二甲基E2甲酯对人胃酸分泌的影响。
Prostaglandins. 1973 Jul;4(1):71-83. doi: 10.1016/0090-6980(73)90057-9.
5
Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.口服前列腺素E₂及其15-甲基类似物对胃液分泌的影响。
Br Med J. 1973 Jan 20;1(5846):143-6. doi: 10.1136/bmj.1.5846.143.
6
Gastric secretory inhibition by certain methyl analogs of prostaglandin E2 following intestinal administration in man.人肠道给药后某些前列腺素E2甲基类似物对胃分泌的抑制作用。
Scand J Gastroenterol. 1974 Nov;9(8):759-62.
7
Gastric secretory inhibition induced by three methyl analogs of prostaglandin E2 administered intragastrically to man.前列腺素E2的三种甲基类似物经胃内给药对人体产生的胃分泌抑制作用。
Scand J Gastroenterol. 1974 Nov;9(8):751-8.
8
Effect of 15(R)15 methylprostaglandin E2 methyl ester on healing of gastric ulcers. Controlled endoscopic study.15（R）-15-甲基前列腺素E2甲酯对胃溃疡愈合的影响。对照内镜研究。
Lancet. 1974 Jul 6;2(7871):10-2. doi: 10.1016/s0140-6736(74)91346-4.
9
10
Effects of an orally administered prostaglandin analogue (16, 16-dimethyl prostaglandin E2) on human gastric secretion.口服前列腺素类似物（16,16-二甲基前列腺素E2）对人胃液分泌的影响。
Gastroenterology. 1975 Sep;69(3):607-11.
Zotero 插件