Karim S M, Carter D C, Bhana D, Ganesan P A
Br Med J. 1973 Jan 20;1(5846):143-6. doi: 10.1136/bmj.1.5846.143.
The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.
研究了口服前列腺素E(2)及其合成的15-甲基类似物对人体胃液分泌的影响。母体E(2)化合物不抑制基础分泌,而15(S)15-甲基-E(2)甲酯及其异构体15(R)15-甲基-E(2)甲酯均抑制基础胃酸分泌。这种作用可能是对壁细胞的直接作用,并且可能在消化性溃疡的治疗中具有价值。