口服前列腺素E₂及其15-甲基类似物对胃液分泌的影响。
Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.
作者信息
Karim S M, Carter D C, Bhana D, Ganesan P A
出版信息
Br Med J. 1973 Jan 20;1(5846):143-6. doi: 10.1136/bmj.1.5846.143.
Abstract
The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.
摘要
研究了口服前列腺素E(2)及其合成的15-甲基类似物对人体胃液分泌的影响。母体E(2)化合物不抑制基础分泌，而15(S)15-甲基-E(2)甲酯及其异构体15(R)15-甲基-E(2)甲酯均抑制基础胃酸分泌。这种作用可能是对壁细胞的直接作用，并且可能在消化性溃疡的治疗中具有价值。
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本文引用的文献
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Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat.前列腺素E1对大鼠胃液分泌及溃疡形成的影响。
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