用于治疗胃十二指肠溃疡的甲基前列腺素E2类似物
Methyl-prostaglandin E2 analogues for healing of gastro-duodenal ulcers.
作者信息
Rybicka J, Gibiński K
出版信息
Scand J Gastroenterol. 1978;13(2):155-9. doi: 10.3109/00365527809181742.
PMID:345414
Abstract
117 patients were submitted to the randomized double-blind clinical trial. Methylated analogues of prostaglandin E2 administered orally markedly suppressed gastric acid secretion and--in comparison to placebo--accelerated cicatrization of duodenal ulcers, but not of gastric ulcers. The resistance of some ulcers to healing was not dependent on gastric acid secretion.
摘要
117名患者参与了随机双盲临床试验。口服前列腺素E2的甲基化类似物可显著抑制胃酸分泌，与安慰剂相比，可加速十二指肠溃疡的愈合，但对胃溃疡无效。一些溃疡难以愈合并不取决于胃酸分泌。
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