College of Life Sciences, Nankai University, Tianjin, 300071, China.
College of Life Sciences, Nankai University, Tianjin, 300071, China.
Food Chem Toxicol. 2020 Dec;146:111803. doi: 10.1016/j.fct.2020.111803. Epub 2020 Oct 6.
This study aimed to investigate the therapeutic effect of curcumin on type 2 diabetes and its underlying mechanisms. A type 2 diabetes mellitus rat model was established by providing high-fat diet and low doses of streptozotocin. Type 2 diabetes mellitus rats were treated with low dose and high dose of curcumin for 8 weeks. The results showed that high-dose curcumin significantly reduced fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase, liver coefficient, and malondialdehyde levels, and BCL2-Associated X expression in the type 2 diabetes mellitus rats. High-dose curcumin increased the levels of liver superoxide dismutase, catalase, and glutathione; as well as the expression of liver B-cell lymphoma-2, phosphatidylinositol 3-kinase, phosphorylated phosphatidylinositol 3-kinase, protein kinase B, and phosphorylated protein kinase B in type 2 diabetes mellitus rats. Furthermore, it ameliorated the histological structure of the liver and pancreas in diabetes mellitus model rats. However, low-dose curcumin had no significant effect on diabetes mellitus model rats. The results suggest that adequate doses of curcumin controls type 2 diabetes mellitus development as well as the mechanism involved in its anti-apoptotic actions and phosphatidylinositol 3-hydroxy kinase/protein kinase B signal pathway regulation in the liver.
本研究旨在探讨姜黄素对 2 型糖尿病的治疗作用及其作用机制。通过给予高脂肪饮食和低剂量链脲佐菌素建立 2 型糖尿病大鼠模型。用低剂量和高剂量姜黄素治疗 2 型糖尿病大鼠 8 周。结果表明，高剂量姜黄素可显著降低 2 型糖尿病大鼠的空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肝系数和丙二醛水平，以及 BCL2 相关 X 的表达。高剂量姜黄素增加了肝超氧化物歧化酶、过氧化氢酶和谷胱甘肽的水平；以及肝 B 细胞淋巴瘤-2、磷酸肌醇 3-激酶、磷酸化磷酸肌醇 3-激酶、蛋白激酶 B 和磷酸化蛋白激酶 B 在 2 型糖尿病大鼠中的表达。此外，它改善了糖尿病模型大鼠的肝和胰腺组织学结构。然而，低剂量姜黄素对糖尿病模型大鼠没有显著影响。结果表明，足够剂量的姜黄素可控制 2 型糖尿病的发展，以及其在肝脏中的抗细胞凋亡作用及其对磷酸肌醇 3-激酶/蛋白激酶 B 信号通路的调节机制。
