Zhou Han-Yu, Yang Han-Xue, Cui Xi-Long, Shi Li-Juan, Gong Jing-Bo, Lui Simon S Y, Cheung Eric F C, Watanabe Katsumi, Chan Raymond C K
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
J Psychiatr Res. 2020 Dec;131:255-262. doi: 10.1016/j.jpsychires.2020.10.002. Epub 2020 Oct 4.
Altered behavioural responses to sensory stimuli, including both hypo- and hyper-reactivity, have been found in individuals with schizophrenia. However, how specific sensory responsiveness patterns are associated with symptomatology of schizophrenia remains largely unknown. The present study aimed to examine sensory responsiveness in typically-developing (TD) adolescents (n = 98) and adolescents with early-onset schizophrenia (EOS) (n = 29) and investigate the relationship between schizotypal traits and sensory responsiveness patterns. All participants completed the Adult/Adolescent Sensory Profile (AASP), the Schizotypal Personality Questionnaire (SPQ) and the Autism Spectrum Quotient (AQ). Results showed that higher levels of hypersensitivity and hyposensitivity coexisted in EOS patients and were correlated with positive and negative symptoms of schizophrenia. Atypical sensory experiences except for sensory seeking were found to be positively correlated with higher levels of schizotypal traits regardless of diagnostic status. Moreover, the strength and pattern of such correlations were comparable in both EOS and TD groups. This study also provided evidence that higher levels of autistic traits would intensify the positive correlation between schizotypal traits and sensory responsiveness abnormalities, suggesting an additive effect of co-occurring schizotypal and autistic traits on atypical sensory experiences. These findings extend previous research by depicting sensory responsiveness patterns in younger populations with schizophrenia, and may have implications for future development of sensory-related interventions in clinical settings.
在精神分裂症患者中发现了对感觉刺激的行为反应改变，包括反应低下和反应过度。然而，特定的感觉反应模式如何与精神分裂症的症状学相关联，在很大程度上仍然未知。本研究旨在检查发育正常（TD）的青少年（n = 98）和早发性精神分裂症（EOS）青少年（n = 29）的感觉反应，并研究分裂型特质与感觉反应模式之间的关系。所有参与者都完成了成人/青少年感觉概况（AASP）、分裂型人格问卷（SPQ）和自闭症谱系商数（AQ）。结果显示，EOS患者中同时存在较高水平的超敏反应和低敏反应，且与精神分裂症的阳性和阴性症状相关。无论诊断状态如何，除了感觉寻求之外的非典型感觉体验都与较高水平的分裂型特质呈正相关。此外，这种相关性的强度和模式在EOS组和TD组中相当。本研究还提供了证据表明，较高水平的自闭症特质会加强分裂型特质与感觉反应异常之间的正相关，表明同时出现的分裂型和自闭症特质对非典型感觉体验有累加效应。这些发现通过描绘精神分裂症年轻人群的感觉反应模式扩展了先前的研究，并可能对临床环境中与感觉相关的干预措施的未来发展具有启示意义。
