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造血干细胞移植后青少年患者严重 2019 年冠状病毒病感染。

Severe Coronavirus Disease 2019 Infection in an Adolescent Patient After Hematopoietic Stem Cell Transplantation.

机构信息

Division of Pediatric Critical Care Medicine, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, NY; Department of Pediatrics, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, NY.

Department of Pediatrics, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, NY.

出版信息

Chest. 2020 Oct;158(4):e139-e142. doi: 10.1016/j.chest.2020.05.579.

Abstract

Infection with the severe acute respiratory syndrome coronavirus 2 causes severe acute lung injury in approximately 5% of infected adults, but few reports have been made of severe pediatric disease. We present an adolescent patient who contracted severe acute respiratory syndrome coronavirus 2 one week after a paternal haplo-identical hematopoietic stem cell transplant, with development of severe hyperferritinemic acute lung injury and macrophage activation-like syndrome. We present her case and a comparison of her laboratory data with those of a cohort of pediatric patients with coronavirus disease 2019 without severe disease.

摘要

感染严重急性呼吸综合征冠状病毒 2 会导致约 5%的成年感染者发生严重急性肺损伤,但鲜有儿童疾病的严重报告。我们报告了 1 例青少年患者,在其父 HLA 单倍体相合造血干细胞移植后 1 周感染严重急性呼吸综合征冠状病毒 2,发展为严重的高铁蛋白血症性急性肺损伤和巨噬细胞活化样综合征。我们介绍了她的病例,并将她的实验室数据与一组无严重疾病的儿童 2019 冠状病毒病患者的数据进行了比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f9/7533688/45bed9a82540/gr1_lrg.jpg

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