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米糠蛋白来源肽的降压作用。

Anti-Hypertensive Effects of Peptides Derived from Rice Bran Protein.

机构信息

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan.

出版信息

Nutrients. 2020 Oct 7;12(10):3060. doi: 10.3390/nu12103060.

DOI:10.3390/nu12103060
PMID:33036355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7600238/
Abstract

Hypertension is one of the major risk factors for arteriosclerosis. Anti-hypertensive peptides derived from animal proteins, such as milk, eggs and fish, are well studied. Anti-hypertensive peptides have also been identified from plant proteins such as soybeans. Rice bran, a byproduct of white rice polishing, is rich in protein and its high protein efficiency ratio is well known. This review discusses the anti-hypertensive peptides identified from rice bran protein and their mechanisms. In addition, we describe protease-digested rice bran from which functional peptides have not been isolated.

摘要

高血压是动脉粥样硬化的主要危险因素之一。源于动物蛋白的抗高血压肽,如牛奶、鸡蛋和鱼类,已经得到了充分的研究。源于植物蛋白的抗高血压肽也已被鉴定出来,如大豆。米糠是白米抛光的副产品,富含蛋白质,其蛋白质功效比值很高。本文综述了从米糠蛋白中鉴定出的具有降血压作用的肽及其作用机制。此外,我们还描述了蛋白酶消化米糠,但尚未从其中分离出具有功能的肽。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/9f118606d786/nutrients-12-03060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/1952bcc32162/nutrients-12-03060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/362555ff62ac/nutrients-12-03060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/cdcb2480d9d8/nutrients-12-03060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/dd3eedce0ae0/nutrients-12-03060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/9f118606d786/nutrients-12-03060-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/1952bcc32162/nutrients-12-03060-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/362555ff62ac/nutrients-12-03060-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/cdcb2480d9d8/nutrients-12-03060-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/dd3eedce0ae0/nutrients-12-03060-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1834/7600238/9f118606d786/nutrients-12-03060-g005.jpg

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本文引用的文献

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Appl Physiol Nutr Metab. 2020 Sep;45(9):917-926. doi: 10.1139/apnm-2019-0757. Epub 2020 Jul 24.
2
Antihypertensive Effect and Safety Evaluation of Rice Bran Hydrolysates from Sang-Yod Rice.桑榆米糠水解物的降压作用及安全性评价。
Plant Foods Hum Nutr. 2020 Mar;75(1):89-95. doi: 10.1007/s11130-019-00789-9.
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Physiological Multifunctions of Rice Proteins of Endosperm and Bran.
Foods. 2023 Jan 1;12(1):183. doi: 10.3390/foods12010183.
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The Updated Review on Plant Peptides and Their Applications in Human Health.植物肽及其在人类健康中的应用的最新综述
Int J Pept Res Ther. 2022;28(5):135. doi: 10.1007/s10989-022-10437-7. Epub 2022 Jul 27.
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Evaluation of anti-cancer and anti-covid-19 properties of cationic pentapeptide Glu-Gln-Arg-Pro-Arg, from rice bran protein and its d-isomer analogs through molecular docking simulations.评价大米糠蛋白来源的正五肽 Glu-Gln-Arg-Pro-Arg 及其 d-异构体类似物通过分子对接模拟的抗癌和抗新冠病毒-19 性质。
J Mol Graph Model. 2021 Nov;108:107999. doi: 10.1016/j.jmgm.2021.107999. Epub 2021 Jul 31.
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Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang.发酵大豆衍生食品——昌德宫的生理活性的最新研究进展。
Int J Mol Sci. 2021 May 27;22(11):5746. doi: 10.3390/ijms22115746.
水稻胚乳和麸皮蛋白质的生理多功能性
J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S42-S47. doi: 10.3177/jnsv.65.S42.
4
Rice Bran Supplement Containing A Functional Substance, the Novel Peptide Leu-Arg-Ala, has Anti-Hypertensive Effects: A Double-Blind, Randomized, Placebo-Controlled Study.米糠补充剂含有一种功能性物质,新型肽 Leu-Arg-Ala,具有降血压作用:一项双盲、随机、安慰剂对照研究。
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5
Vasorelaxant and Antihypertensive Effects That Are Dependent on the Endothelial NO System Exhibited by Rice Bran-Derived Tripeptide.米糠衍生三肽具有血管舒张和降压作用,且依赖于内皮型一氧化氮合酶系统。
J Agric Food Chem. 2019 Feb 6;67(5):1437-1442. doi: 10.1021/acs.jafc.8b06341. Epub 2019 Jan 28.
6
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