Qin Sen, Hu YaoFeng, Luo HuaSong, Chu Wei, Deng RuCui, Ma JinLiang
Department of Orthopedics, The First Affiliated Hospital of YangTze University, Jingzhou, Hubei, China.
Department of Neurological Care Unit, The First Affiliated Hospital of YangTze University, Jingzhou, Hubei, China.
Front Immunol. 2025 Mar 17;16:1513834. doi: 10.3389/fimmu.2025.1513834. eCollection 2025.
Bone cancer remains a significant challenge in oncology, with limited success in current therapeutic approaches, particularly immunotherapy. Emerging research highlights the potential of integrating metal ions and nanomaterials for targeted immunotherapy in bone cancer. Metal ions, including calcium, magnesium, and zinc, play a significant role in modulating immune responses within the tumor microenvironment, affecting essential pathways necessary for immune activation. Meanwhile, nanomaterials, particularly metallic nanoparticles, offer precise drug delivery and immune system modulation, improving the efficacy of immunotherapeutic agents. This review explores the synergistic effects of metal ion-nanomaterial conjugates, discussing their role in enhancing immune cell activation, particularly T-cells and macrophages, and their potential for controlled drug release. We highlight preclinical advancements in bone cancer treatment using metal ion-responsive nanoparticles, and address current challenges such as biocompatibility and toxicity. Finally, we discuss the future prospects of these technologies in personalized and precision medicine, aiming to revolutionize bone cancer immunotherapy.
骨癌仍然是肿瘤学领域的一项重大挑战，目前的治疗方法，尤其是免疫疗法，成效有限。新兴研究凸显了整合金属离子和纳米材料用于骨癌靶向免疫治疗的潜力。包括钙、镁和锌在内的金属离子在调节肿瘤微环境中的免疫反应方面发挥着重要作用，影响着免疫激活所必需的关键途径。与此同时，纳米材料，尤其是金属纳米颗粒，能够实现精准的药物递送和免疫系统调节，提高免疫治疗药物的疗效。本综述探讨了金属离子-纳米材料共轭物的协同效应，讨论了它们在增强免疫细胞激活，特别是T细胞和巨噬细胞激活方面的作用，以及它们在控制药物释放方面的潜力。我们强调了使用金属离子响应性纳米颗粒在骨癌治疗方面的临床前进展，并阐述了当前诸如生物相容性和毒性等挑战。最后，我们讨论了这些技术在个性化和精准医学中的未来前景，旨在彻底改变骨癌免疫治疗。
