Chema S, Chumo R S, Dolan T T, Gathuma J M, Irvin A D, James A D, Young A S
Vet Rec. 1987 Jun 13;120(24):575-7. doi: 10.1136/vr.120.24.575.
A field trial was undertaken to test the efficacy of halofuginone lactate in the treatment of East Coast fever under farming conditions in Kenya. The drug was administered orally at a dose of 1.2 mg/kg bodyweight and treatment was repeated after 48 hours. Of 293 cases treated 236 (80.5 per cent) recovered and 49 (16.7 per cent) died. Five animals were disposed of by the owners and three became chronically infected. No differences were recorded in recovery rate between uncomplicated cases and cases with concurrent anaplasmosis or babesiosis, nor were there any significant differences in recovery rates between animals of different types. However, zebu cattle (Bos indicus) tended to respond more rapidly to treatment than exotic cattle (Bos taurus). Younger animals had a poorer recovery rate than adults. Early treatments were more successful than those administered late. It was concluded that with early detection and treatment, coupled with efficient tick control, halofuginone lactate is effective in the treatment of clinical East Coast fever under field conditions.
在肯尼亚的养殖条件下，进行了一项田间试验，以测试乳酸盐常山酮治疗东海岸热的疗效。该药物以1.2毫克/千克体重的剂量口服给药，并在48小时后重复治疗。在293例接受治疗的病例中，236例（80.5%）康复，49例（16.7%）死亡。5只动物被主人处理掉，3只发生慢性感染。单纯病例与同时患有无形体病或巴贝斯虫病的病例之间的康复率没有差异，不同类型动物的康复率也没有显著差异。然而，瘤牛（Bos indicus）对治疗的反应往往比外来牛（Bos taurus）更快。年幼动物的康复率比成年动物低。早期治疗比晚期治疗更成功。得出的结论是，通过早期检测和治疗，再加上有效的蜱虫控制，乳酸盐常山酮在田间条件下对临床东海岸热的治疗是有效的。
