Güneysu Fatih, Guner Necip Gokhan, Erdem Ali Fuat, Durmus Ensar, Durgun Yesim, Yurumez Yusuf
Department of Emergency Medicine, Sakarya University Training and Research Hospital, Turkey.
Department of AnesthesioIogy and Reanimation, Faculty of Medicine, Sakarya University, Turkey.
J Coll Physicians Surg Pak. 2020 Sep;30(9):928-932. doi: 10.29271/jcpsp.2020.09.928.
To investigate the association of white blood cell (WBC) counts, neutrophil, platelets, lymphocyte counts, C-reactive protein (CRP), neutrophil / lymphocyte ratio (NLR), derived NLR ratio (d-NLR), and platelet / lymphocyte ratio (PLR) at the time of first admission for mortality caused by COVID-19.
Descritive, analytical study.
Department of Emergency Medicine, Sakarya University Training and Research Hospital, Turkey from March 2020 to May 2020.
One hundred and sixty-nine patients with the diagnosis of Covid-19 were retrospectively reviewed. Patients were divided into two groups as survivors and non-survivors. Inclusion criteria were age ≥18 years, RT-PCR test positivity, hospitalisation. Patients with missing data were excluded. Data regarding age, gender, WBC counts, neutrophil, platelets, and lymphocyte, CRP, NLR, d-NLR, PLR and comorbid conditions were analysed for mortality. All tests were done with a two-sided significance of 5%. For each endpoint, the absolute and relative effects and their corresponding 95% confidence ınterval were calculated.
There was a statistically significant association between neutrophil, lymphocyte, CRP, NLR, d-NLR and PLR values (p=0.005, p<0.001, p<0.001, p<0.001, p<0.001, and p<0.001, respectively) with mortality status of the patients. The cutoff values calculated by this analysis were 67.50 years for age, 5.12 K / µl for neutrophil, 1.12 K / µl for lymphocyte, 67.78 mg / dl for CRP, 3.9 for NLR, 2.55 for d-NLR, and 148.85 for PLR.
Altered neutrophil and lymphocyte counts, NLR, d-NLR, PLR, and CRP values can be used as early predictors of mortality in Covid-19 patients. Key Words: Covid-19, Mortality, Emergency, NLR, d-NLR, PLR.
探讨新型冠状病毒肺炎（COVID-19）首次入院时白细胞（WBC）计数、中性粒细胞、血小板、淋巴细胞计数、C反应蛋白（CRP）、中性粒细胞/淋巴细胞比值（NLR）、衍生NLR比值（d-NLR）和血小板/淋巴细胞比值（PLR）与死亡率的相关性。
描述性、分析性研究。
2020年3月至2020年5月，土耳其萨卡里亚大学培训与研究医院急诊科。
回顾性分析169例确诊为COVID-19的患者。患者分为存活组和非存活组。纳入标准为年龄≥18岁、逆转录聚合酶链反应（RT-PCR）检测阳性、住院治疗。排除数据缺失的患者。分析年龄、性别、WBC计数、中性粒细胞、血小板、淋巴细胞、CRP、NLR、d-NLR、PLR及合并症等数据与死亡率的关系。所有检验的双侧显著性水平为5%。对于每个终点，计算绝对和相对效应及其相应的95%置信区间。
中性粒细胞、淋巴细胞、CRP、NLR、d-NLR和PLR值与患者的死亡状态之间存在统计学显著相关性（p值分别为0.005、<0.001、<0.001、<0.001、<0.001和<0.001）。该分析计算出的临界值为年龄67.50岁、中性粒细胞5.12 K/µl、淋巴细胞1.12 K/µl、CRP 67.78 mg/dl、NLR 3.9、d-NLR 2.55、PLR 148.85。
中性粒细胞和淋巴细胞计数、NLR、d-NLR、PLR及CRP值的改变可作为COVID-19患者死亡率的早期预测指标。关键词：COVID-19；死亡率；急诊；NLR；d-NLR；PLR
