Department of Biology, Southern Oregon University, Ashland, OR 97520, USA.
Department of Chemistry, Southern Oregon University, Ashland, OR 97520, USA.
J Exp Biol. 2020 Nov 20;223(Pt 22):jeb223867. doi: 10.1242/jeb.223867.
Oxidative stress, which occurs from an imbalance of reactive oxygen and nitrogen species (RONS) and both endogenous and exogenous antioxidants, promotes aging and underlies sex-specific differences in longevity and susceptibility to age-related neurodegeneration. Recent evidence suggests that curcumin, a yellow pigment derived from turmeric and shown to exhibit antioxidant properties as a RONS scavenger, influences the regulation of genetic elements in endogenous antioxidant pathways. To investigate the role of curcumin in sex-specific responses to oxidative stress, were reared on media supplemented with 0.25, 2.5 or 25 mmol l curcuminoids (consisting of curcumin, demethoxycurcumin and bisdemethoxycurcumin) and resistance to oxidative stress and neural parameters were assessed. High levels of curcuminoids exhibited two sex-specific effects: protection from hydrogen peroxide as an oxidative stressor and alterations in turning rate in an open field. Taken together, these results suggest that the influence of curcuminoids as antioxidants probably relies on changes in gene expression and that sexual dimorphism exists in the response to curcuminoids.
氧化应激是由于活性氧和氮物种（RONS）以及内源性和外源性抗氧化剂之间的不平衡而产生的，它会促进衰老，并导致寿命和对与年龄相关的神经退行性变的易感性存在性别特异性差异。最近的证据表明，姜黄素是一种从姜黄中提取的黄色色素，具有作为 RONS 清除剂的抗氧化特性，它影响内源性抗氧化途径中遗传元素的调节。为了研究姜黄素在氧化应激的性别特异性反应中的作用，将其在补充有 0.25、2.5 或 25 mmol l 姜黄素类（由姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素组成）的培养基中培养，并评估其对氧化应激和神经参数的抗性。高水平的姜黄素类表现出两种性别特异性效应：对过氧化氢作为氧化应激源的保护作用，以及在开阔场中的转弯率的改变。总之，这些结果表明，姜黄素类作为抗氧化剂的影响可能依赖于基因表达的变化，并且在对姜黄素类的反应中存在性别二态性。
