严重 2019 冠状病毒病（COVID-19）患者的氧合血红蛋白解离曲线左移。
A left shift in the oxyhaemoglobin dissociation curve in patients with severe coronavirus disease 2019 (COVID-19).
机构信息
Intensive Care Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Centre for Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
出版信息
Br J Haematol. 2020 Nov;191(3):390-393. doi: 10.1111/bjh.17128. Epub 2020 Oct 10.
Abstract
Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb-O ) affinity. Calculated oxygen tension at half-saturation (p ) was on average (±SD) 3·3 (3·13) mmHg lower than the normal p value (23·4 vs. 26·7 mmHg; P < 0·0001). Compared to an unmatched historic control of patients with other causes of severe respiratory failure, patients with COVID-19 had a significantly higher Hb-O affinity (mean [SD] p 23·4 [3·13] vs. 24·6 [5.4] mmHg; P < 0·0001). We hypothesise that, due to the long disease process, acclimatisation to hypoxaemia could play a role.
摘要
患有 2019 年冠状病毒病 (COVID-19) 的危重症患者会出现低氧血症，并需要机械通气来支持气体交换。我们对来自 COVID-19 患者的血气分析 (n = 3518) 进行了回顾性观察研究，以研究血红蛋白氧 (Hb-O) 亲和力的变化。平均 (±SD) 计算得到的半饱和度时氧分压 (p) 比正常 p 值低 3.3 (3.13) mmHg（23.4 比 26.7 mmHg；P < 0.0001）。与其他严重呼吸衰竭原因的未匹配历史对照相比，COVID-19 患者的 Hb-O 亲和力显著更高（平均 [SD] p 23.4 [3.13] 比 24.6 [5.4] mmHg；P < 0.0001）。我们假设，由于疾病持续时间较长，对低氧血症的适应可能起作用。
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