口腔鳞状细胞癌患者的生存和预后因素。
Survival and prognostic factors in patients with oral squamous cell carcinoma.
机构信息
Department of Pathology Avenida Professor Moraes Rego, 1235 CEP 50670-901, Recife, Pernambuco, Brazil
出版信息
Med Oral Patol Oral Cir Bucal. 2021 May 1;26(3):e387-e392. doi: 10.4317/medoral.24242.
BACKGROUND
This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC).
MATERIAL AND METHODS
Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors.
RESULTS
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58).
CONCLUSIONS
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis.
背景
本研究旨在评估影响口腔鳞状细胞癌（OSCC）患者总生存率（OS）的社会人口学和临床因素。
材料与方法
对 1999 年至 2013 年期间在巴西东北部一家公立医院就诊的 547 例 OSCC 患者的病历进行评估。采用 Kaplan-Meier 方法进行生存分析。评估年龄、性别、种族、临床分期、解剖部位、治疗方式和合并症对患者预后的影响。使用 Cox 比例风险回归模型确定独立的预后因素。
结果
5 年 OS 率为 39%。多因素分析显示，年龄<40 岁（HR=2.20；95%CI：1.02-4.72）和单一治疗方式（HR=1.91；95%CI：1.37-2.67）与预后不良相关，而早期临床分期则导致更好的结果（HR=0.38；95%CI：0.25-0.58）。
结论
临床分期较晚、诊断时年龄较小、接受单一治疗方式的 OSCC 患者预后较差。
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