Altern Ther Health Med. 2022 Feb;28(2):70-77.
The use of herbal/ herbal products has increased from more than a decade. Other than increasing the safety and efficacy of these products, the public needs to be aware of the possible interactions that could occur when combined with conventional drug therapy. Despite the lack of sufficient information on the safety of herbal products, their use as an alternative and complementary medicine is globally widespread. Herbal medicines are now mainly used in active pharmaceutical ingredients. Concurrent usage of natural and prescription medicines is of significant concern. The most significant therapeutic consequence of this approach is the herbal-drug interface (HDI). The proof of HDI is of various degrees of clinical significance utilizing a formal assessment method. Pharmacodynamics HDIs are also recognized for the inherent pharmacological effects of phytochemicals.
The main concern is to mainly highlight the most common Herb-Drug interaction concerning most common herbal-drug interaction.
The current review mainly focused on the literature available for the drug-drug interaction in case of most commonly used herbal drugs. Some of the evidence has been compiled through extensive literature survey on different database platforms like Pubmed, Embase and google scholar supporting our review in every aspect of drug-drug interactions reported in these ten years, our team has also tried of including some previous studies by researchers.
The data reliability of such data can be questionable in terms of authenticity, but due to availability of some documented case reports, the risk for HDI will be evaluated in a not-clinical health evaluation step of the product development cycle for the increasing number of plant-based pharmacological activities. The primary concern which was seen to be worried was the self-medication of many herbal drugs which are readily available OTC for the consumers. Available evidence on HDIs is inadequate for therapeutic uses; thus, it may need further clinical studies. This is valid from in vitro trials, and clinical research tested for herbal-drugs interactions.
The purpose of this article was to gather data to cater an evidence-based discussion and information for providing complete knowledge to existing patients and consumers regarding herbal drug-drug interactions, would also help them a brief knowledge that what can go wrong in case of herbal-drug interaction, in conclusion, we also found that there is still no basic guideline defining the drug-drug interactions.
十多年来，草药/草药产品的使用有所增加。除了提高这些产品的安全性和疗效外，公众还需要意识到当与常规药物治疗联合使用时可能发生的潜在相互作用。尽管关于草药产品安全性的信息不足，但它们作为替代和补充药物在全球范围内广泛使用。草药现在主要用于活性药物成分。同时使用天然药物和处方药是一个值得关注的问题。这种方法的最重要治疗后果是草药-药物相互作用（HDI）。使用正式评估方法证明 HDI 具有不同程度的临床意义。由于植物化学物质的固有药理作用，也认识到药效学 HDI。
主要关注的是主要强调最常见的与最常见草药-药物相互作用有关的草药-药物相互作用。
本综述主要集中在可用于最常用草药药物相互作用的文献上。通过在 Pubmed、Embase 和谷歌学术等不同数据库平台上进行广泛的文献调查，收集了一些证据，以支持我们在这十年中报告的药物相互作用的各个方面的综述，我们的团队还尝试包括一些研究人员的先前研究。
此类数据的可靠性在真实性方面可能值得怀疑，但由于有一些记录在案的病例报告，因此在产品开发周期的非临床健康评估步骤中，将评估基于植物的药理学活性增加的情况下发生 HDI 的风险。被认为令人担忧的主要问题是许多草药药物的自我用药，这些药物对消费者来说是现成的 OTC。关于 HDI 的现有证据不足以用于治疗用途；因此，可能需要进一步的临床研究。这适用于从体外试验到经过临床试验测试的草药-药物相互作用的研究。
本文的目的是收集数据，为提供基于证据的讨论和信息提供依据，为现有患者和消费者提供有关草药药物相互作用的完整知识，也将帮助他们了解在草药药物相互作用的情况下可能会出现什么问题，总之，我们还发现目前还没有定义药物相互作用的基本准则。
