Department of Pharmacovigilance, Moroccan Poison Control and Pharmacovigilance Center, Rabat, Morocco.
Drug Saf. 2012 Oct 1;35(10):785-91. doi: 10.1007/BF03261975.
Adverse drug reactions, including those resulting from interactions between herbal medicines and conventional drugs, are a public health problem worldwide. The need for pharmacovigilance for herb-drug interactions (HDIs) is essential for the identification and assessment of risks of using herbal products (questionable safety, efficacy and quality), which are not always tested with rigor, or often not subject to approval by regulatory agencies. Spontaneous and active surveillance conducted by national pharmacovigilance centres permits a rapid detection of potentially harmful combinations of products. The incidence and prevalence of HDIs are difficult to predict because of the underreporting of adverse effects. It is important for health professionals, consumers, regulatory authorities and suppliers of herbal medicines to be aware of the possible adverse effects and drug interactions caused when herbal medicines are co-administered with conventional drugs. National pharmacovigilance centres continue to play a significant role in increasing awareness of drug safety, in this case with HDIs. The authors' objective for this paper is to provide awareness among policy makers responsible for the design of appropriate pharmacovigilance practices and therefore to highlight the importance of pharmacovigilance in the safety monitoring of HDIs.
药物不良反应，包括草药与常规药物相互作用引起的不良反应，是一个全球性的公共卫生问题。草药-药物相互作用（HDIs）的药物警戒是识别和评估使用草药产品（安全性、疗效和质量存在疑问）风险的必要条件，这些产品并非总是经过严格测试，也常常不受监管机构批准。国家药物警戒中心进行的自发和主动监测可快速检测出产品中可能存在的有害组合。由于不良反应报告不足，HDIs 的发生率和患病率难以预测。当草药与常规药物同时使用时，卫生专业人员、消费者、监管机构和草药供应商了解可能产生的不良反应和药物相互作用非常重要。国家药物警戒中心在提高药物安全性意识方面继续发挥重要作用，在这种情况下是针对 HDIs。作者撰写本文的目的是提高负责制定适当药物警戒实践的决策者的认识，因此强调药物警戒在 HDIs 安全性监测中的重要性。
